Jacklet J W, Rine J
Proc Natl Acad Sci U S A. 1977 Mar;74(3):1267-71. doi: 10.1073/pnas.74.3.1267.
The gill withdrawal reflex of Aplysia has been used as a model for studying the neuronal mechanisms of habituation, a behavioral plasticity. We have assessed the contribution of neuromuscular facilitation, an elementary synaptic plasticity, during habituation of the reflex by recording gill muscle potentials, which we show are caused by excitatory junctional potentials. These potentials show systematic frequency-dependent changes in amplitude. The gill withdrawal evoked by central motor neuron firing during each habituation trial is determined by facilitation of the excitatory junctional potentials during the trial and the facilitated state of the initial excitatory junctional potential in a trial, determined by neuron activity prior to the trial. The neuromuscular junctions, therefore, act like a frequency-dependent amplifier of central motor activity. They are fully responsive to the dynamic changes of motor neuron firing that occurs during habituation and especially after dishabituation.
海兔的鳃收缩反射已被用作研究习惯化（一种行为可塑性）的神经元机制的模型。我们通过记录鳃肌电位来评估神经肌肉易化（一种基本的突触可塑性）在反射习惯化过程中的作用，我们发现这些电位是由兴奋性接头电位引起的。这些电位在幅度上呈现出系统的频率依赖性变化。在每次习惯化试验中，由中枢运动神经元放电诱发的鳃收缩是由试验期间兴奋性接头电位的易化以及试验中初始兴奋性接头电位的易化状态决定的，而初始兴奋性接头电位的易化状态由试验前的神经元活动决定。因此，神经肌肉接头就像一个中枢运动活动的频率依赖性放大器。它们对习惯化过程中尤其是去习惯化后发生的运动神经元放电的动态变化具有完全的反应性。
