海兔鳃缩反射习惯化所涉及的突触抑制的量子分析
A quantal analysis of the synaptic depression underlying habituation of the gill-withdrawal reflex in Aplysia.
作者信息
Castellucci V F, Kandel E R
出版信息
Proc Natl Acad Sci U S A. 1974 Dec;71(12):5004-8. doi: 10.1073/pnas.71.12.5004.
Abstract
Habituation, one of the simplest behavioral paradigms for studying memory, has recently been examined on the cellular level in the gill-withdrawal reflex in the mollusc Aplysia and in the escape response in cray-fish. In both cases short-term habituation involved a decrease in excitatory synaptic transmission at the synapses between the sensory neurons and their central target cells. To analyze the mechanisms of the synaptic depression in Aplysia, we applied a quantal analysis to synaptic transmission between the sensory and motor neurons of the gill-withdrawal reflex. Our results indicate that short-term habituation results from a presynaptic mechanism: a decrease in the number of transmitter quanta released per impulse. The sensitivity of the postsynaptic receptor remains unaltered.
摘要
习惯化是研究记忆最简单的行为模式之一，最近在软体动物海兔的鳃收缩反射以及小龙虾的逃避反应中，从细胞层面进行了研究。在这两种情况下，短期习惯化都涉及感觉神经元与其中枢靶细胞之间突触处兴奋性突触传递的减少。为了分析海兔中突触抑制的机制，我们对鳃收缩反射的感觉神经元和运动神经元之间的突触传递进行了量子分析。我们的结果表明，短期习惯化是由突触前机制导致的：每次冲动释放的递质量子数量减少。突触后受体的敏感性保持不变。
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