呼气峰值流量和用力呼气量的日变化
Diurnal Variation in Peak Expiratory Flow and Forced Expiratory Volume.
作者信息
Goel Arun, Goyal Manish, Singh Ruchi, Verma Narsingh, Tiwari Sunita
机构信息
Assistant Professor, Department of Physiology, All India Institute of Medical Science , Rishikesh, Uttarakhand, India .
Assistant Professor, Department of Physiology, All India Institute of Medical Science , Bhubaneswar, Odisha, India .
出版信息
J Clin Diagn Res. 2015 Oct;9(10):CC05-7. doi: 10.7860/JCDR/2015/15156.6661. Epub 2015 Oct 1.
INTRODUCTION
Diurnal variability in airways has most commonly been reported using peak expiratory flow (PEF) and forced expiratory volume in one second (FEV1). Characteristics of variability in small, mid and large airways caliber are expected to be different but have not been studied.
AIM
The aim of the study was to assess diurnal variation in small mid and large airways caliber using FEF25, FEF50, FEF75 and FEF25-75 along with PEF and FEV1 in healthy subjects.
MATERIALS AND METHODS
Spirometry was performed in 161 healthy subjects twice in a day. Diurnal variability in FEF25, FEF50, FEF75, FEF25-75, PEF and FEV1 were determined and compared.
RESULTS
It revealed that all parameters exhibit significant diurnal variability. Diurnal variability is highest in large airways and lowest in smaller airways.
CONCLUSION
Proximal airways show greater diurnal variation in their caliber than distal airways as reflected by greater variability in PEF as compared to FEV1.
引言
气道的昼夜变化最常通过呼气峰值流速（PEF）和一秒用力呼气容积（FEV1）来报告。小气道、中等气道和大气道管径变化的特征预计会有所不同，但尚未得到研究。
目的
本研究的目的是在健康受试者中，使用用力呼气流量25%（FEF25）、用力呼气流量50%（FEF50）、用力呼气流量75%（FEF75）和用力呼气流量25%-75%（FEF25-75）以及PEF和FEV1来评估小气道、中等气道和大气道管径的昼夜变化。
材料与方法
对161名健康受试者进行一天两次的肺活量测定。测定并比较FEF25、FEF50、FEF75、FEF25-75、PEF和FEV1的昼夜变化。
结果
结果显示所有参数均呈现显著的昼夜变化。大气道的昼夜变化最大，小气道的昼夜变化最小。
结论
近端气道管径的昼夜变化大于远端气道，这可通过与FEV1相比PEF更大的变化反映出来。
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