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脐带血血液学指标的生物学参考区间:在印度南部一家三级医疗中心进行的一项研究。

Biological Reference Interval for Hematological Profile of Umbilical Cord Blood: A Study Conducted at A Tertiary Care Centre in South India.

作者信息

Suman Febe Renjitha, Raj Reddy S Sudheer, Priyathersini N, Rajendran Rithika, Rajendran Rashmika, Ramadoss Umalakshmi

机构信息

Professor, Department of Pathology, Sri Ramachandra Medical College and Research Institute , Porur, Chennai, India .

Student, Department of Pathology, Sri Ramachandra Medical College and Research Institute , Porur, Chennai, India .

出版信息

J Clin Diagn Res. 2015 Oct;9(10):SC07-9. doi: 10.7860/JCDR/2015/14713.6675. Epub 2015 Oct 1.

Abstract

INTRODUCTION

Umbilical cord blood (UCB) a source of hematopoietic stem cells, is also an acceptable sample to assess neonatal sepsis. Though reports are available for stem cell counts very minimal literature is available regarding hematologic parameters, which may vary on ethnicity.

AIM

To establish biological reference interval for hematological parameters of umbilical cord blood to guide neonatologists, hematopoietic stem cell transplant specialists and future analysis.

MATERIALS AND METHODS

Prospective longitudinal study was done from January 2014 to April 2014 after ethics committee approval. UCB from 120 full term new borns of normal birth weight born out of uneventful pregnancy to mothers aged between 21 to 45 years with hemoglobin above 10g/dL were processed in Beckman Coulter LH780 analyzer for complete blood count and counter checked by peripheral smear. Results tabulated in Microsoft excel are analyzed using IBM SPSS statistics 16 software.

RESULTS

Male to female ratio is 1:1.05. There is no difference in the values between males and females. When compared with few studies available, though many values are comparable a few values are not comparable.

CONCLUSION

This study can be a useful guide to neonatologists, hematopoietic stem cells transplant hematologists and future analysis.

摘要

引言

脐带血是造血干细胞的一个来源,也是评估新生儿败血症的可接受样本。虽然有关于干细胞计数的报告,但关于血液学参数的文献非常少,而这些参数可能因种族而异。

目的

建立脐带血血液学参数的生物学参考区间,以指导新生儿科医生、造血干细胞移植专家及未来的分析。

材料与方法

在伦理委员会批准后,于2014年1月至2014年4月进行了前瞻性纵向研究。对120例出生体重正常的足月儿的脐带血进行处理,这些新生儿的母亲年龄在21至45岁之间,孕期正常,血红蛋白高于10g/dL,使用贝克曼库尔特LH780分析仪进行全血细胞计数,并通过外周血涂片进行复查。在Microsoft excel中制表的结果使用IBM SPSS statistics 16软件进行分析。

结果

男女比例为1:1.05。男性和女性之间的值没有差异。与现有的少数研究相比,虽然许多值具有可比性,但有一些值不可比。

结论

本研究可为新生儿科医生、造血干细胞移植血液科医生及未来的分析提供有用的指导。

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