Adewumi Adediran, Titilope A Adeyemo, Akinsegun Akinbami A, Abidoye Gbadegesin, Ebele Uche, Sulaimon Akanmu A
Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos.
Department of Obstetrics and Gynaecology, Lagos State University College of Medicine, Ikeja, Nigeria.
Pan Afr Med J. 2014 Mar 13;17:192. doi: 10.11604/pamj.2014.17.192.3680. eCollection 2014.
Full blood count (FBC), one of the most frequently requested for laboratory investigations, is a simple, fast and cheap test and is a reliable indicator of health. Due to its usefulness in the assessment of health status of individuals, its parameters in cord blood, a major source of haemopoietic stem cell transplantation and an ideal source for laboratory investigations for newborns were determined to provide a useful guide to local neonatologists and stem cell transplant physicians.
Three millilitres of umbilical cord blood was collected from 130 normal birth weight newborns (69 males and 61 females) whose cord were clamped immediately after delivery, at a teaching hospital in Lagos, Nigeria and full blood count parameters were determined using Sysmex autoanalyzer, model KX-21N. Consented mothers of the newborns were selected based on, age between 18 and 45 years; uneventful pregnancy and delivery and haemoglobin (Hb) concentration ≥ 10 g/dL.
There were no statistical gender differences in the mean values of Hb concentrations (M = 13.27 ±1.60 g/dL; F = 13.32±1.61g/dL; p = 0.93), total white cell count (M = 3.16±5.43 × 10(9)/L; F = 13.07±4.98 × 10(9)/L; p= 0.92), platelet count (M= 223.64± 64.21 × 10(9)/L; F = 226.69±80.83 × 10(9)/L; p = 0.81) and other parameters.
Mean values of full blood count parameters obtained in this study are comparable to reports from other studies in developing countries and could be a useful guide for neonatologists and stem cell transplant physicians in our geographical location.
全血细胞计数(FBC)是最常要求进行的实验室检查之一,是一项简单、快速且廉价的检测,是健康状况的可靠指标。鉴于其在评估个体健康状况方面的实用性,对脐带血中的参数进行了测定,脐带血是造血干细胞移植的主要来源,也是新生儿实验室检查的理想来源,旨在为当地新生儿科医生和干细胞移植医生提供有用的指导。
在尼日利亚拉各斯的一家教学医院,从130名正常出生体重的新生儿(69名男性和61名女性)中采集3毫升脐带血,这些新生儿在出生后立即夹紧脐带,并使用Sysmex KX-21N型号的自动分析仪测定全血细胞计数参数。入选的新生儿母亲需符合以下条件:年龄在18至45岁之间;妊娠和分娩过程顺利;血红蛋白(Hb)浓度≥10 g/dL。
血红蛋白浓度(男性均值=13.27±1.60 g/dL;女性均值=13.32±1.61g/dL;p = 0.93)、白细胞总数(男性均值=3.16±5.43×10⁹/L;女性均值=13.07±4.98×10⁹/L;p= +0.92)、血小板计数(男性均值=223.64±64.21×10⁹/L;女性均值=226.69±80.83×10⁹/L;p = 0.81)及其他参数的均值在性别上无统计学差异。
本研究中获得的全血细胞计数参数均值与其他发展中国家的研究报告相当,可为我们所在地区的新生儿科医生和干细胞移植医生提供有用的指导。