HTLV-1 ORF-I 编码蛋白与宿主免疫反应的调控：病毒诱导的细胞内信号失调。
HTLV-1 ORF-I Encoded Proteins and the Regulation of Host Immune Response: Viral Induced Dysregulation of Intracellular Signaling.
机构信息
Universidade Federal do Rio de Janeiro (UFRJ), Rua Rodolpho Paulo Rocco 255, 3° Andar, Cidade Universitária, Ilha do Fundão, 21941-913 Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro (UFRJ), Rua Rodolpho Paulo Rocco 255, 3° Andar, Cidade Universitária, Ilha do Fundão, 21941-913 Rio de Janeiro, RJ, Brazil ; Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rua Mariz e Barros 775, Tijuca, 20270-901 Rio de Janeiro, RJ, Brazil.
出版信息
J Immunol Res. 2015;2015:498054. doi: 10.1155/2015/498054. Epub 2015 Oct 18.
The human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus associated with both proliferative and inflammatory disorders. This virus causes a persistent infection, mainly in CD4+ T lymphocyte. The ability to persist in the host is associated with the virus capacity to evade the immune response and to induce infected T-cell proliferation, once the HTLV-1 maintains the infection mainly by clonal expansion of infected cells. There are several evidences that ORF-I encoded proteins, such as p12 and p8, play an important role in this context. The present study will review the molecular mechanisms that HTLV-1 ORF-I encoded proteins have to induce dysregulation of intracellular signaling, in order to escape from immune response and to increase the infected T-cell proliferation rate. The work will also address the impact of ORF-I mutations on the human host and perspectives in this study field.
人类 T 细胞嗜淋巴细胞病毒 1 型（HTLV-1）是一种逆转录病毒，与增殖性和炎症性疾病有关。该病毒引起持续性感染，主要感染 CD4+T 淋巴细胞。病毒能够在宿主体内存续与其逃避免疫反应和诱导受感染 T 细胞增殖的能力有关，一旦 HTLV-1 通过感染细胞的克隆扩增维持感染，就会发生这种情况。有几项证据表明，ORF-I 编码的蛋白质，如 p12 和 p8，在这种情况下发挥着重要作用。本研究将综述 HTLV-1 ORF-I 编码蛋白诱导细胞内信号转导失调的分子机制，以逃避免疫反应并提高受感染 T 细胞的增殖率。该工作还将讨论 ORF-I 突变对人类宿主的影响以及该研究领域的展望。
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