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腹膜外腹腔镜前列腺癌根治术:一位外科医生对171例患者进行的为期2年的前瞻性研究经验。

Extraperitoneal laparoscopic radical prostatectomy: A prospective 2-year single-surgeon experience with 171 cases.

作者信息

Leitão Tito Palmela, Papatsoris Athanasios G, Mandron Eric

机构信息

Urology Department, Clinique Chirurgicale du Pré, Le Mans, France.

出版信息

Arab J Urol. 2012 Dec;10(4):347-52. doi: 10.1016/j.aju.2012.09.001. Epub 2012 Oct 27.

Abstract

OBJECTIVE

To assess the safety and the oncological and functional efficacy of a prospective series of extraperitoneal laparoscopic radical prostatectomy (ELRP).

PATIENTS AND METHODS

This prospective study included 171 consecutive patients (mean age 62.9 years, SD 6.5) who underwent ELRP by one surgeon between January 2008 and December 2009. The variables analysed were operative duration, blood loss, conversion rate, complications, hospital stay, duration of catheterisation, and the oncological results. We also assessed the rates of continence and erectile function.

RESULTS

There were no conversions to open surgery. The mean (SD) operative duration was 112.7 (19.4) min, the blood loss was 372.1 (219.1) mL, the hospital stay was 6.8 (2.0) days, and the duration of catheterisation 6.7 (1.5) days. Collectively, 23.4% (40/171) of patients had positive surgical margins. Urinary continence at 1, 3, 6 and 12 months was achieved in 63.3% (95/150), 88.6% (78/88), in 90.3% (121/134) and 92.1% (117/127) of patients, respectively. The respective percentages for physiological erections after nerve-sparing ELRP at the same times were 11.8% (13/110), 11.8% (13/110), 18.2% (20/110) and 25.5% (28/110). The overall potency recovery rates (including patients on pharmacotherapy) were, respectively, 26.4% (29/110), 35.5% (39/110), 52.7% (58/110) and 69.1% (76/110), for the nerve-sparing procedure.

CONCLUSION

ELRP gave good oncological and functional results, especially in terms of urinary continence.

摘要

目的

评估一系列前瞻性腹膜外腹腔镜根治性前列腺切除术(ELRP)的安全性、肿瘤学及功能疗效。

患者与方法

这项前瞻性研究纳入了2008年1月至2009年12月期间由一名外科医生连续实施ELRP手术的171例患者(平均年龄62.9岁,标准差6.5)。分析的变量包括手术时长、失血量、中转率、并发症、住院时间、导尿时间以及肿瘤学结果。我们还评估了控尿率和勃起功能。

结果

无中转开腹手术病例。平均(标准差)手术时长为112.7(19.4)分钟,失血量为372.1(219.1)毫升,住院时间为6.8(2.0)天,导尿时间为6.7(1.5)天。总体而言,23.4%(40/171)的患者手术切缘阳性。术后1、3、6和12个月时,控尿患者比例分别为63.3%(95/150)、88.6%(78/88)、90.3%(121/134)和92.1%(117/127)。保留神经的ELRP术后同期生理性勃起的相应比例分别为11.8%(13/110)、11.8%(13/110)、18.2%(20/110)和25.5%(28/110)。保留神经手术的总体性功能恢复率(包括接受药物治疗的患者)分别为26.4%(29/110)、35.5%(39/110)、52.7%(58/110)和69.1%(76/110)。

结论

ELRP在肿瘤学及功能方面取得了良好效果,尤其是在控尿方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca6a/4442966/4e43a61935ef/fx1.jpg

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