Research Unit for General Practice, Aarhus University, Aarhus, Denmark.
Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
JAMA Psychiatry. 2015 Dec;72(12):1227-34. doi: 10.1001/jamapsychiatry.2015.2094.
Parental death from suicide is associated with increased risk of suicide in the bereaved child, but little is known about the long-term risks of suicide after parental death from other causes. A better understanding of this association may improve suicide prevention efforts.
To examine the long-term risks of suicide after parental death and how the risk trajectories differed by cause of parental death while accounting for major potential confounding variables.
DESIGN, SETTING, AND PARTICIPANTS: A population-based matched cohort study was performed using information from nationwide registers (data from 1968 to 2008) in 3 Scandinavian countries (for a total of 7,302,033 persons). We identified 189,094 children (2.6%) who had a parent who died before the child reached 18 years of age (ie, the bereaved cohort). Each bereaved child was matched by sex and age to 10 children who did not have a parent who died before they reached 18 years of age (for a total of 1,890,940 children) (ie, the reference cohort). Both cohorts were followed for up to 40 years. Poisson regression was used to calculate the incidence rate ratio (IRR), while accounting for age at parental death, sex, time since bereavement, maternal/paternal death, birth order, family history of psychiatric illness, and socioeconomic status. Data analyses were finalized June 24, 2015.
The main exposure was death of a parent within the first 18 years of life.
Incidence of suicide among persons who had a parent who died during their childhood.
During follow-up, 265 bereaved persons (0.14%) and 1342 nonbereaved persons (0.07%) died of suicide (IRR = 2.02 [95% CI, 1.75-2.34]); IRR = 3.44 (95% CI, 2.61-4.52) for children who had a parent who died of suicide, and IRR = 1.76 (95% CI, 1.49-2.09) for children who had a parent who died of other causes. The IRR tended to be higher for children who had a parent who died before they reached 6 years of age, and the IRR remained high for at least 25 years. During 25 years of follow-up, the absolute risk of suicide was 4 in 1000 persons for boys who experienced parental death and 2 in 1000 persons for girls who experienced parental death.
Parental death in childhood is, irrespective of cause, associated with an increased long-term risk of suicide. The consequences of parental death in childhood are far-reaching, and suicide risk trajectories may be influenced by early-life conditions. Future public health efforts should consider helping highly distressed children to cope with bereavement.
父母因自杀而亡与丧亲儿童自杀风险增加相关,但对于父母因其他原因死亡后儿童自杀的长期风险知之甚少。更好地了解这种关联可能会改善自杀预防工作。
在考虑主要潜在混杂变量的情况下,检查父母死亡后长期自杀风险,以及自杀风险轨迹如何因父母死亡原因而异。
设计、地点和参与者:本研究采用来自 3 个斯堪的纳维亚国家(1968 年至 2008 年)全国登记册(总计 7302033 人)中的信息,开展了一项基于人群的匹配队列研究。我们确定了 189094 名(2.6%)在 18 岁之前父母去世的儿童(即丧亲队列)。每个丧亲儿童按性别和年龄与未在 18 岁之前父母去世的 10 名儿童相匹配(总计 1890940 名儿童)(即参照队列)。两个队列都最多随访 40 年。使用泊松回归计算发病率比(IRR),同时考虑到父母死亡时的年龄、性别、丧亲时间、母亲/父亲死亡、出生顺序、精神疾病家族史和社会经济地位。数据分析于 2015 年 6 月 24 日完成。
主要暴露是父母在生命的前 18 年死亡。
有父母在童年时期去世的人群的自杀发生率。
在随访期间,265 名丧亲者(0.14%)和 1342 名非丧亲者(0.07%)死于自杀(IRR=2.02[95%CI,1.75-2.34]);因自杀而父母死亡的儿童的 IRR 为 3.44(95%CI,2.61-4.52),因其他原因而父母死亡的儿童的 IRR 为 1.76(95%CI,1.49-2.09)。对于父母在 6 岁之前死亡的儿童,IRR 往往更高,并且至少 25 年内保持较高水平。在 25 年的随访期间,男孩经历父母死亡的自杀绝对风险为每 1000 人中 4 人,女孩经历父母死亡的自杀绝对风险为每 1000 人中 2 人。
儿童时期父母的死亡与长期自杀风险增加有关,无论原因如何。儿童时期父母的死亡后果深远,自杀风险轨迹可能受生命早期条件的影响。未来的公共卫生工作应考虑帮助极度痛苦的儿童应对丧亲之痛。