直接 C-H 烯丙基化 N-酰基/砜基四氢异喹啉及其类似物。
Direct C-H Allylation of N-Acyl/Sulfonyl Tetrahydroisoquinolines and Analogues.
机构信息
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University , Tianjin, 300071, People's Republic of China.
出版信息
Org Lett. 2015 Nov 20;17(22):5714-7. doi: 10.1021/acs.orglett.5b03042. Epub 2015 Nov 11.
A highly efficient direct C-H allylation reaction at the α position of N-acyl/sulfonyl tetrahydroisoquinolines under mild conditions was developed. The reaction was also suitable for allylation of other protected nitrogen-containing heterocycles. Several interesting transformations of the products into valuable synthetic intermediates are featured with the successful total synthesis of (±)-crispine A.
发展了一种在温和条件下高效的直接 C-H 烯丙基化反应，该反应发生在 N-酰基/磺酰基四氢异喹啉的α 位。该反应也适用于其他保护的含氮杂环的烯丙基化。通过成功地全合成（±）-crispine A，展示了产物转化为有价值的合成中间体的几个有趣的转化。
Zotero 插件