呋喃西林对聚丙烯网片修复伴纤维组织包裹的腹壁缺损的影响。
Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue.
作者信息
Yasojima Edson Yuzur, Ribeiro Júnior Rubens Fernando Gonçalves, Pessôa Thyago Cezar Prado, Cavalcante Lainy Carollyne da Costa, Ramos Suzana Rodrigues, Serruya Yuri Aarão Amaral, de Moraes Mateus Malta
机构信息
Department of General Surgery, Universidade Estadual do Pará, Belem, PA, Brazil.
UEPA, Belem, PA, Brazil.
出版信息
Acta Cir Bras. 2015 Oct;30(10):686-90. doi: 10.1590/S0102-865020150100000006.
PURPOSE
To evaluate the effects of nitrofurazone on the correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue in rats.
METHODS
A defect in the abdominal wall was created and corrected with polypropylene mesh in 20 rats. They were randomly distributed into four groups: control, fibrous mesh, nitrofurazone and nitrofurazone dip in the mesh. Euthanasia was performed in 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects.
RESULTS
All animals had adhesions. However, no statistically significant difference (p>0.05) when compared between groups. Similarly microscopic analysis, in which there was no statistical significance level for the evaluated parameters such as mono and polymorphonuclear lymphocytes, granuloma, fibrosis, necrosis and collagen proliferation.
CONCLUSION
There was no significant effect on the abdominal wall defect repair with polypropylene mesh surrounded by fibrous tissue when dipped in nitrofurazone 2%.
目的
评估呋喃西林对大鼠聚丙烯网片修复腹壁缺损时纤维组织包裹的影响。
方法
在20只大鼠身上制造腹壁缺损并用聚丙烯网片修复。将它们随机分为四组：对照组、纤维网片组、呋喃西林组和网片浸呋喃西林组。术后21天实施安乐死。从网片以及宏观和微观方面分析愈合过程。
结果
所有动物均有粘连。然而，组间比较时无统计学显著差异（p>0.05）。同样，微观分析中，对于所评估的参数如单核和多形核淋巴细胞、肉芽肿、纤维化、坏死和胶原增殖，均无统计学显著水平。
结论
用2%呋喃西林浸泡的被纤维组织包裹的聚丙烯网片修复腹壁缺损时，无显著效果。
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