Pokrywczynska Marta, Adamowicz Jan, Czapiewska Monika, Balcerczyk Daria, Jundzill Arkadiusz, Nowacki Maciej, Petros Peter, Drewa Tomasz
a Department of Regenerative Medicine , Nicolaus Copernicus University in Torun, Ludwik Rydygier Medical College in Bydgoszcz , Bydgoszcz , Poland.
b Professorial Department of Surgery , St Vincent's Hospital, University of New South Wales , Sydney , Australia.
Expert Opin Biol Ther. 2016;16(2):233-42. doi: 10.1517/14712598.2016.1118459. Epub 2015 Dec 4.
Controversy exists regarding the therapeutic benefit of cell-based therapy in the treatment of stress urinary incontinence (SUI).
The aim of this systematic review was to evaluate evidence regarding the therapeutic effect and safety of cell-based therapy in the treatment of SUI and to propose a new approach to SUI treatment utilizing tissue engineering methodologies. We have thoroughly reviewed the literature using PubMed in order to identify only original, clinical studies involving cell therapy for SUI.
Cell-based therapy, as practiced today, is a safe but ineffective method for SUI treatment. The key to an optimal therapeutic outcome in SUI is accurate diagnosis combined with targeted therapy. Targeted therapy in SUI should be based on cell implantation to restore and regenerate the damaged urethral sphincter and/or the construction of a neo-pubourethral ligament utilizing tissue engineering methodologies.
关于基于细胞的疗法在压力性尿失禁（SUI）治疗中的治疗益处存在争议。
本系统评价的目的是评估基于细胞的疗法在SUI治疗中的治疗效果和安全性的证据，并提出一种利用组织工程方法治疗SUI的新方法。我们使用PubMed对文献进行了全面回顾，以仅识别涉及SUI细胞治疗的原始临床研究。
目前实施的基于细胞的疗法是一种安全但对SUI治疗无效的方法。SUI获得最佳治疗效果的关键是准确诊断并结合靶向治疗。SUI的靶向治疗应基于细胞植入以修复和再生受损的尿道括约肌，和/或利用组织工程方法构建新的耻骨尿道韧带。
