Kuwabara Satoshi
Department of Neurology, Graduate School of Medicine, Chiba University.
Brain Nerve. 2015 Nov;67(11):1371-6. doi: 10.11477/mf.1416200308.
Fisher syndrome has been regarded as a peculiar inflammatory neuropathy with ophthalmoplegia, ataxia, and areflexia, whereas Bickerstaff brainstem encephalitis has been considered a pure central nervous system disease characterized by ophthalmoplegia, ataxia, and consciousness disturbance. Both disorders share common features including preceding infection, albumin-cytological dissociation, and association with Guillain-Barré syndrome. The discovery of anti-GQ1b IgG antibodies further supports the view that the two disorders represent a single disease spectrum. The lesions in Fisher syndrome and Bickerstaff brainstem encephalitis are presumably determined by the expression of ganglioside GQ1b in the human peripheral and central nervous systems. Bickerstaff brainstem encephalitis is likely to represent a variant of Fisher syndrome with central nervous system involvement.
费希尔综合征被认为是一种伴有眼肌麻痹、共济失调和无反射的特殊炎性神经病，而比克尔斯塔夫脑干脑炎则被视为一种以眼肌麻痹、共济失调和意识障碍为特征的纯中枢神经系统疾病。这两种疾病具有共同特征，包括前驱感染、蛋白细胞分离以及与吉兰-巴雷综合征相关。抗GQ1b IgG抗体的发现进一步支持了这两种疾病代表单一疾病谱的观点。费希尔综合征和比克尔斯塔夫脑干脑炎的病变可能由神经节苷脂GQ1b在人类外周和中枢神经系统中的表达所决定。比克尔斯塔夫脑干脑炎可能是费希尔综合征伴有中枢神经系统受累的一种变体。
