床边心脏型脂肪酸结合蛋白（H-FABP）：是心脏性晕厥的早期预测标志物。
Bedside heart type fatty acid binding protein (H-FABP): Is an early predictive marker of cardiac syncope.
作者信息
Sonmez Bedriye Muge, Ozturk Derya, Yilmaz Fevzi, Altinbilek Ertugrul, Kavalci Cemil, Durdu Tamer, Hakbilir Oktay, Turhan Turan, Ongar Murat
机构信息
Department of Emergency Medicine, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Emergency Medicine Department, Sisli Etfal Education and Research Hospital, Istanbul, Turkey.
出版信息
J Pak Med Assoc. 2015 Nov;65(11):1156-60.
OBJECTIVE
To determine the value of bedside heart-type fatty acid binding protein in diagnosis of cardiac syncope in patients presenting with syncope or presyncope.
METHODS
The prospective study was conducted at Ankara Numune Training and Research Hospital, Ankara, Turkey, between September 1, 2010, and January 1, 2011, and comprised patients aged over 18 years who presented with syncope or presyncope. Patients presenting to emergency department within 4 hours of syncope or presyncope underwent a bedside heart-type fatty acid binding protein test measurement. SPSS 16 was used for statistical analysis.
RESULTS
Of the 100 patients evaluated, 22(22%) were diagnosed with cardiac syncope. Of them, 13(59.1%) patients had a positive and 9(40.9%) had a negative heart-type fatty acid binding protein result. Consequently, the test result was 12.64 times more positive in patients with cardiac syncope compared to those without.
CONCLUSIONS
Bedside heart-type fatty acid binding protein, particularly at early phase of myocardial injury, reduces diagnostic and therapeutic uncertainity of cardiac origin in syncope patients.
目的
确定床旁检测心脏型脂肪酸结合蛋白对晕厥或先兆晕厥患者心脏性晕厥的诊断价值。
方法
前瞻性研究于2010年9月1日至2011年1月1日在土耳其安卡拉努穆内培训与研究医院进行，纳入年龄超过18岁的晕厥或先兆晕厥患者。在晕厥或先兆晕厥发作4小时内就诊于急诊科的患者接受了床旁心脏型脂肪酸结合蛋白检测。采用SPSS 16进行统计分析。
结果
在评估的100例患者中，22例（22%）被诊断为心脏性晕厥。其中，13例（59.1%）患者心脏型脂肪酸结合蛋白检测结果为阳性，9例（40.9%）为阴性。因此，心脏性晕厥患者的检测结果阳性率比非心脏性晕厥患者高12.64倍。
结论
床旁心脏型脂肪酸结合蛋白检测，尤其是在心肌损伤早期，可减少晕厥患者心脏源性病因的诊断和治疗不确定性。
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