患有脑淀粉样血管病的痴呆患者的脑脊液生物标志物

Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy.

作者信息

Li Yan-feng, Ge Fang-fang, Zhang Yong, You Hui, Zhang Zhen-xin

出版信息

Chin Med Sci J. 2015 Sep;30(3):170-3. doi: 10.1016/s1001-9294(15)30042-0.

DOI:10.1016/s1001-9294(15)30042-0

PMID:26564416

Abstract

OBJECTIVE

To study the changes of biomarkers in cerebrospinal fluid (CSF) in cerebral amyloid angiopathy (CAA) dementia and Alzheimer(')s disease.

METHODS

Levels of amyloid protein β (Aβ42, Aβ40) and phosphorylated Tau-protein (P-tau) in CSF and ratio of Aβ42/Aβ40 were tested in 5 cases with CAA dementia and 20 cases with Alzheimer's disease collected at Peking Union Medical College Hospital from December 2001 to March 2011.

RESULTS

The levels of Aβ42, Aβ40, and P-tau in CSF and ratio of Aβ42/Aβ40 were (660.4 ± 265.2) ng/L, (7111.0 ± 1033.4) ng/L, (71.8 ± 51.5) ng/L, and 0.077 ± 0.033, respectively in CAA dementia and (663.6 ± 365.6) ng/L, (5115.0 ± 2931.1) ng/L, (47.7 ± 38.8) ng/L, and 0.192 ± 0.140, respectively in Alzheimer's disease patients. There were no statistically significant differences between CAA dementia and Alzheimer's disease in terms of these CSF biomarkers (all P>0.05).

CONCLUSION

Measurements of CSF biomarkers may not be helpful in differential diagnosis of CAA and Alzheimer's disease.

摘要

目的

研究脑淀粉样血管病（CAA）痴呆和阿尔茨海默病患者脑脊液（CSF）中生物标志物的变化。

方法

对2001年12月至2011年3月在北京协和医院收集的5例CAA痴呆患者和20例阿尔茨海默病患者的脑脊液中淀粉样蛋白β（Aβ42、Aβ40）和磷酸化Tau蛋白（P-tau）水平以及Aβ42/Aβ40比值进行检测。

结果

CAA痴呆患者脑脊液中Aβ42、Aβ40、P-tau水平及Aβ42/Aβ40比值分别为（660.4±265.2）ng/L、（7111.0±1033.4）ng/L、（71.8±51.5）ng/L和0.077±0.033，阿尔茨海默病患者分别为（663.6±365.6）ng/L、（5115.0±2931.1）ng/L、（47.7±38.8）ng/L和0.192±0.140。这些脑脊液生物标志物在CAA痴呆和阿尔茨海默病之间无统计学显著差异（所有P>0.05）。