Zhang Yue, Shi Jufang, Huang Huiyao, Ren Jiansong, Li Ni, Dai Min
National Office for Cancer Prevention and Control, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
National Office for Cancer Prevention and Control, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China; Email:
Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Jul;36(7):709-14.
To understand the incidence and mortality of colorectal cancer in China.
The data from GLOBOCAN 2012, Chinese Cancer Registry Annual Report 2012, Cancer Incidence in Five Continents (CI5), the Three National Death Cause Surveys in China and WHO Mortality Database were used to learn about the incidence and mortality of colorectal cancer and related trends in China.
It was estimated by GLOBOCAN 2012 that in 2012 the age-standardized incidence of colorectal cancer in China was 16.9 per 100 000 in males and 11.6 per 100 000 in females, and the age-standardized mortality was 9.0 per 100 000 in males and 6.1 per 100 000 in females. GLOBOCAN 2012 estimated that colorectal cancer incidence and mortality would increase with the level of human development index. China's human development level was high, suggesting that the burden of colorectal cancer would be more serious in China with the development of social economy. The data from CI5 Volume IV and GLOBOCAN 2012 indicated that the incidence of colorectal cancer began to increase obviously at age of 50 years in China. Chinese Cancer Registry Annual Report 2012 showed that the incidence and mortality of colorectal cancer in urban population were two times higher than those in rural population in 2009, the proportions of colon cancer among colorectal and anus cancers, which was 49.0% in males and 54.2% in females, 53.4% in urban population and 41.7% in rural population. CI5 Volumes IV-X showed that colon cancer and rectum and anus cancer incidence in Shanghai for both males and females were increasing during the period 1973-2007. The percentage change in colon cancer and rectum and anus cancer incidence between 1973-1977 and 2003-2007 increased by 138.8% and 31.1% in males, 146.7% and 49.1% in females, respectively. The data from the Three National Death Cause Surveys showed that the crude mortality of colorectal cancer increased by 77.9% form mid 1970's (1973-1975) to mid 2000's (2004-2005). WHO Mortality Database showed that average annual percentage change (AAPC) of age-standardized colorectal cancer mortality increased by 0.7% (P < 0.05) from 1987 to 2000.
More attention should be paid to the prevention and control of colorectal cancer in urban area and in male population in China. Similar to the western countries, the burden of colorectal cancer in China would continue to become serious if no population based prevention and control programs are conducted.
了解中国结直肠癌的发病率和死亡率。
使用全球癌症负担数据库（GLOBOCAN）2012年的数据、《中国肿瘤登记年报》2012年版、《五大洲癌症发病率》（CI5）、中国三次国家死因调查数据以及世界卫生组织死亡率数据库，来了解中国结直肠癌的发病率、死亡率及相关趋势。
全球癌症负担数据库（GLOBOCAN）2012年估计，2012年中国男性结直肠癌年龄标准化发病率为16.9/10万，女性为11.6/10万；年龄标准化死亡率男性为9.0/10万，女性为6.1/10万。全球癌症负担数据库（GLOBOCAN）2012年估计，结直肠癌发病率和死亡率将随着人类发展指数水平的提高而上升。中国的人类发展水平较高，这表明随着社会经济的发展，中国结直肠癌的负担将更加严重。《五大洲癌症发病率》第四卷和全球癌症负担数据库（GLOBOCAN）2012年的数据表明，中国结直肠癌发病率在50岁时开始明显上升。《中国肿瘤登记年报》2012年显示，2009年城市人群结直肠癌发病率和死亡率是农村人群的两倍，在结直肠癌和肛管癌中结肠癌的比例，男性为49.0%，女性为54.2%，城市人群为53.4%，农村人群为41.7%。《五大洲癌症发病率》第四卷至第十卷显示，1973 - 2007年期间，上海男性和女性结肠癌以及直肠和肛管癌的发病率均呈上升趋势。1973 - 1977年至2003 - 2007年期间，男性结肠癌和直肠及肛管癌发病率的变化百分比分别增加了138.8%和31.1%，女性分别增加了146.7%和49.1%。中国三次国家死因调查数据显示，结直肠癌粗死亡率从20世纪70年代中期（1973 - 1975年）到21世纪初（2004 - 2005年）增加了77.
