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本文引用的文献

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Opioid Prescribing in a Cross Section of US Emergency Departments.美国急诊科横断面研究中的阿片类药物处方情况
Ann Emerg Med. 2015 Sep;66(3):253-259.e1. doi: 10.1016/j.annemergmed.2015.03.026. Epub 2015 May 4.
2
Emergency department-initiated buprenorphine/naloxone treatment for opioid dependence: a randomized clinical trial.急诊科启动的丁丙诺啡/纳洛酮治疗阿片类药物依赖:一项随机临床试验。
JAMA. 2015 Apr 28;313(16):1636-44. doi: 10.1001/jama.2015.3474.
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Trends in opioid analgesic abuse and mortality in the United States.美国阿片类镇痛药滥用和死亡率的趋势。
N Engl J Med. 2015 Jan 15;372(3):241-8. doi: 10.1056/NEJMsa1406143.
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Presentation of prescription and nonprescription opioid overdoses to US emergency departments.美国急诊科收治的处方和非处方阿片类药物过量病例情况。
JAMA Intern Med. 2014 Dec;174(12):2034-7. doi: 10.1001/jamainternmed.2014.5413.
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Primary care-based buprenorphine taper vs maintenance therapy for prescription opioid dependence: a randomized clinical trial.基于初级保健的丁丙诺啡递减疗法与维持治疗用于处方类阿片类药物依赖:一项随机临床试验。
JAMA Intern Med. 2014 Dec;174(12):1947-54. doi: 10.1001/jamainternmed.2014.5302.
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Brief intervention for patients with problematic drug use presenting in emergency departments: a randomized clinical trial.急诊中存在药物问题的患者的简短干预:一项随机临床试验。
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Trends in U.S. emergency department visits for opioid overdose, 1993-2010.1993 - 2010年美国急诊科因阿片类药物过量就诊的趋势。
Pain Med. 2014 Oct;15(10):1765-70. doi: 10.1111/pme.12461. Epub 2014 Aug 19.
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The dueling obligations of opioid stewardship.
Ann Intern Med. 2014 Aug 19;161(4):307-8. doi: 10.7326/L14-5016-8.
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The changing face of heroin use in the United States: a retrospective analysis of the past 50 years.美国海洛因使用情况的变化:对过去 50 年的回顾性分析。
JAMA Psychiatry. 2014 Jul 1;71(7):821-6. doi: 10.1001/jamapsychiatry.2014.366.
10
Source of prescription drugs used nonmedically in rural and urban populations.农村和城市人口非医疗用途处方药的来源。
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处方止痛药的非医疗用途与急诊科利用率增加:一项全国性调查结果

Non-medical use of prescription pain medications and increased emergency department utilization: Results of a national survey.

作者信息

Frank Joseph W, Binswanger Ingrid A, Calcaterra Susan L, Brenner Lisa A, Levy Cari

机构信息

Division of General Internal Medicine, University of Colorado School of Medicine, 12631 East 17th Avenue, Aurora, CO 80045, United States; VA Eastern Colorado Health Care System, 1055 Clermont Street, Denver, CO 80220, United States.

Division of General Internal Medicine, University of Colorado School of Medicine, 12631 East 17th Avenue, Aurora, CO 80045, United States; Institute for Health Research, Kaiser Permanente Colorado, 10065 East Harvard Avenue, Suite 300, Denver, CO 80231, United States.

出版信息

Drug Alcohol Depend. 2015 Dec 1;157:150-7. doi: 10.1016/j.drugalcdep.2015.10.027. Epub 2015 Oct 29.

DOI:10.1016/j.drugalcdep.2015.10.027
PMID:26564754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4663179/
Abstract

BACKGROUND

There are no population-based studies of emergency department (ED) utilization by individuals using prescription pain medications non-medically. We examined whether non-medical use of prescription pain medications was independently associated with increased ED utilization.

METHODS

We conducted a retrospective analysis of a nationally representative sample of the non-institutionalized, civilian U.S. population in the National Survey on Drug Use and Health, 2008-2013. We used multivariable logistic regression to examine the association between past year ED utilization and non-medical use of prescription pain medications, defined as use of medications "not prescribed for you or that you took only for the experience or feeling they caused".

RESULTS

An estimated 10.5 million adults annually reported past year non-medical use (NMU) of prescription pain medications, and 39%, or 4.1 million adults annually, also reported one or more past year ED visits. After adjustment for sociodemographic and clinical characteristics, adults with past year NMU of prescription pain medications had increased odds of past year ED utilization (adjusted odds ratio 1.32; 95% confidence interval 1.24-1.41). In secondary analyses, individuals with more frequent NMU had increased odds of ED utilization in unadjusted analyses, but this association was attenuated with adjustment for the source of prescription pain medication (i.e., physician, friend/family, other source).

CONCLUSIONS

Non-medical use of prescription pain medications is associated with increased ED utilization. Further work is needed to identify the optimal role of ED settings in providing screening, education, and treatment referral for individuals using prescription pain medications non-medically.

摘要

背景

目前尚无基于人群的关于非医疗使用处方止痛药的个体急诊室(ED)就诊情况的研究。我们研究了非医疗使用处方止痛药是否与急诊室就诊增加独立相关。

方法

我们对2008 - 2013年美国国家药物使用和健康调查中具有全国代表性的非机构化平民样本进行了回顾性分析。我们使用多变量逻辑回归来研究过去一年急诊室就诊与非医疗使用处方止痛药之间的关联,非医疗使用处方止痛药定义为使用“未为您开具或您仅为其所带来的体验或感觉而服用的药物”。

结果

估计每年有1050万成年人报告过去一年非医疗使用(NMU)处方止痛药,其中39%,即每年410万成年人,还报告过去一年有一次或多次急诊室就诊。在对社会人口统计学和临床特征进行调整后,过去一年非医疗使用处方止痛药的成年人过去一年急诊室就诊的几率增加(调整后的优势比为1.32;95%置信区间为1.24 - 1.41)。在二次分析中,非医疗使用频率更高的个体在未调整分析中急诊室就诊的几率增加,但在对处方止痛药来源(即医生、朋友/家人、其他来源)进行调整后,这种关联减弱。

结论

非医疗使用处方止痛药与急诊室就诊增加有关。需要进一步开展工作,以确定急诊室在为非医疗使用处方止痛药的个体提供筛查、教育和治疗转诊方面的最佳作用。