Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands/Department of Physics and Medical Technology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands/Department of Physics and Medical Technology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Mult Scler. 2016 Sep;22(10):1279-88. doi: 10.1177/1352458515615953. Epub 2015 Nov 12.
Gray matter (GM) pathology has high clinical relevance in multiple sclerosis (MS), but conventional magnetic resonance imaging (MRI) is insufficiently sensitive to visualize the rather subtle damage.
To investigate whether high spatial resolution T1-relaxation time (T1-RT) measurements can detect changes in the normal-appearing GM of patients with long-standing MS and whether these changes are associated with physical and cognitive impairment.
High spatial resolution (1.05 × 1.05 × 1.2 mm(3)) T1-RT measurements were performed at 3 T in 156 long-standing MS patients and 54 healthy controls. T1-RT histogram parameters in several regions were analyzed to investigate group differences. Stepwise linear regression analyses were used to assess the relation of T1-RT with physical and cognitive impairment.
In both thalamus and cortex, T1-RT histogram skewness was higher in patients than controls. In the cortex, this was driven by the frontal and temporal lobes. No differences were found in other GM histogram parameters. Cortical skewness, thalamus volume, and average white matter (WM) lesion T1-RT emerged as the strongest predictors for cognitive performance (adjusted R(2) = 0.39).
Subtle GM damage was present in the cortex and thalamus of MS patients, as indicated by increased T1-RT skewness. Increased cortical skewness emerged as an independent predictor of cognitive dysfunction.
灰质（GM）病理学在多发性硬化症（MS）中有很高的临床相关性，但常规磁共振成像（MRI）的敏感性不足以观察到相当微妙的损伤。
研究高空间分辨率 T1 弛豫时间（T1-RT）测量是否可以检测到长期 MS 患者正常外观 GM 的变化，以及这些变化是否与身体和认知障碍有关。
在 3T 下对 156 名长期 MS 患者和 54 名健康对照者进行高空间分辨率（1.05×1.05×1.2mm³）T1-RT 测量。分析了几个区域的 T1-RT 直方图参数以研究组间差异。采用逐步线性回归分析评估 T1-RT 与身体和认知障碍的关系。
在丘脑和皮质中，患者的 T1-RT 直方图偏度均高于对照组。在皮质中，这是由额叶和颞叶驱动的。在其他 GM 直方图参数中未发现差异。皮质偏度、丘脑体积和平均白质（WM）病变 T1-RT 是认知表现的最强预测因子（调整后的 R²=0.39）。
MS 患者的皮质和丘脑存在细微的 GM 损伤，表现为 T1-RT 偏度增加。增加的皮质偏度是认知功能障碍的独立预测因子。
