髓鞘含量降低与认知正常个体认知能力下降更快有关。
Lower myelin content is associated with more rapid cognitive decline among cognitively unimpaired individuals.
机构信息
Magnetic Resonance Physics of Aging and Dementia (MRPAD) Unit, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, Maryland, USA.
Brain Aging and Behavior Section, NIA, NIH, Baltimore, Maryland, USA.
出版信息
Alzheimers Dement. 2023 Jul;19(7):3098-3107. doi: 10.1002/alz.12968. Epub 2023 Jan 31.
INTRODUCTION
The influence of myelination on longitudinal changes in cognitive performance remains unclear.
METHODS
For each participant (N = 123), longitudinal cognitive scores were calculated. Myelin content was probed using myelin water fraction (MWF) or longitudinal relaxation rate (R ); both are MRI measures sensitive to myelin, with MWF being specific.
RESULTS
Lower MWF was associated with steeper declines in executive function (p < .02 in all regions) and lower R was associated with steeper declines in verbal fluency (p < .03 in all regions). Additionally, lower R was associated with steeper declines in executive function (p < .02 in all regions) and memory (p < .04 in occipital and cerebral white matter) but did not survive Bonferroni correction.
DISCUSSION
We demonstrate significant relationships between myelin content and the rates of change in cognitive performance among cognitively normal individuals. These findings highlight the importance of myelin in cognitive functioning and suggest MWF and R as imaging biomarkers to predict cognitive changes.
简介
髓鞘形成对认知表现纵向变化的影响尚不清楚。
方法
对于每个参与者（N=123），计算了纵向认知评分。使用髓鞘水分数（MWF）或纵向弛豫率（R）来探测髓鞘含量；两者都是对髓鞘敏感的 MRI 测量指标，其中 MWF 具有特异性。
结果
MWF 较低与执行功能的下降幅度更大相关（所有区域均<.02），R 较低与言语流畅性的下降幅度更大相关（所有区域均<.03）。此外，R 较低与执行功能（所有区域均<.02）和记忆（枕叶和大脑白质<.04）的下降幅度更大相关，但未通过 Bonferroni 校正。
讨论
我们在认知正常个体中证明了髓鞘含量与认知表现变化率之间存在显著关系。这些发现强调了髓鞘在认知功能中的重要性，并表明 MWF 和 R 作为预测认知变化的成像生物标志物。
Zotero 插件