Yamada Naoshi, Sato Yuichiro, Moriguchi-Goto Sayaka, Yamashita Atsushi, Kodama Yuki, Sameshima Hiroshi, Asada Yujiro
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Department of Diagnostic Pathology, Faculty of Medicine, Miyazaki University Hospital, University of Miyazaki, Miyazaki, Japan.
Placenta. 2015 Dec;36(12):1490-3. doi: 10.1016/j.placenta.2015.10.021. Epub 2015 Nov 2.
Intrauterine inflammation contributes to neonatal infection-related morbidity. A new histological framework of placental inflammation has recently been proposed; however, the association between this method and clinical findings has not been defined. To assess the clinical relevance of this system, we studied placental findings in 272 singleton neonates born at less than 34 weeks gestation. The incidences of sepsis, intraventricular hemorrhage, chronic lung disease, and necrotizing enterocolitis increased in a stepwise fashion with severity of placental inflammation. After adjusting for gestational age, a high grade of fetal inflammation was significantly associated with chronic lung disease and necrotizing enterocolitis.
宫内炎症会导致新生儿感染相关的发病率。最近提出了一种新的胎盘炎症组织学框架；然而，这种方法与临床发现之间的关联尚未明确。为了评估该系统的临床相关性，我们研究了272例孕周小于34周的单胎新生儿的胎盘情况。败血症、脑室内出血、慢性肺病和坏死性小肠结肠炎的发病率随着胎盘炎症的严重程度呈逐步上升趋势。在对孕周进行校正后，高度的胎儿炎症与慢性肺病和坏死性小肠结肠炎显著相关。
