分子时代的真实世界数据——在真实世界中寻找现实。

Real-world data in the molecular era-finding the reality in the real world.

机构信息

Molecular Evidence Development Consortium, Rexburg, Idaho, USA.

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, USA.

出版信息

Clin Pharmacol Ther. 2016 Feb;99(2):186-97. doi: 10.1002/cpt.300. Epub 2016 Jan 12.

DOI:10.1002/cpt.300

PMID:26565654

Abstract

Real-world data (RWD) promises to provide a pivotal element to the understanding of personalized medicine. However, without true representation (or the reality) of the patient-disease biosystem and its molecular contributors, RWD may hamper rather than help this advancement. In this review article, we discuss RWD vs. clinical reality and the disconnects that exist currently (emphasizing molecular medicine), and methods of closing the gaps between RWD and reality.

摘要

真实世界数据（RWD）有望为个性化医学的理解提供关键要素。然而，如果没有对患者-疾病生物系统及其分子贡献者的真实表现（或现实），RWD 可能会阻碍而不是帮助这一进展。在这篇综述文章中，我们讨论了 RWD 与临床现实之间的差异以及目前存在的脱节（强调分子医学），并探讨了弥合 RWD 与现实之间差距的方法。