Xie Daxing, Liu Liang, Osaiweran Hasan, Yu Chaoran, Sheng Fang, Gao Chun, Hu Junbo, Gong Jianping
Tongji Cancer Research Institute, Tongji Hospital, Tongji Medical College in Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College in Huazhong University of Science and Technology, Wuhan, Hubei, China.
PLoS One. 2015 Nov 13;10(11):e0142970. doi: 10.1371/journal.pone.0142970. eCollection 2015.
Gastric cancer is the second leading cause of cancer death worldwide. Here, we propose a novel type of tumor metastasis designated as Metastasis V in gastric cancer. Metastasis V is defined as the appearance of cancer cells in the mesogastrium with perigastric adipose tissue. To detect its incidence and characterize its clinic pathological features, large cross sectional tissue analysis of mesogastrium from 74 patients were used. Metastasis V was detected in 1 of 40 (2.5%) patients with early gastric cancer, 8 of 34 (24%) patients with advanced gastric cancer. The mean distance of Metastasis V from gastric wall was approximately 2.6 cm. Metastasis V was closely associated with tumor invasion depth, along with a number of positive lymph node metastasis. The prognosis of patients with Metastasis V was significantly (P<0.05) worse than those with tumor cell-free mesogastrium. These findings indicate that by using whole-sectional analysis, Metastasis V can be detected in the mesogastrium of gastric cancer patients, and also suggests that it may be a risk factor for patient survival after radical surgery.
胃癌是全球癌症死亡的第二大主要原因。在此，我们提出一种新型的肿瘤转移，在胃癌中称为转移V。转移V定义为癌细胞出现在胃系膜及胃周脂肪组织中。为了检测其发生率并描述其临床病理特征，我们对74例患者的胃系膜进行了大样本横断面组织分析。在40例早期胃癌患者中有1例（2.5%）检测到转移V，在34例进展期胃癌患者中有8例（24%）检测到转移V。转移V距胃壁的平均距离约为2.6厘米。转移V与肿瘤浸润深度密切相关，同时伴有多个阳性淋巴结转移。有转移V的患者预后明显（P<0.05）差于胃系膜无肿瘤细胞的患者。这些发现表明，通过全切片分析，可以在胃癌患者的胃系膜中检测到转移V，这也表明它可能是根治性手术后患者生存的一个危险因素。
