Espinoza L R, Ebers G, Mountcastle W, Zabriskie J B
Acta Neurol Scand Suppl. 1977;63:123-31.
The blastogenic response of MS lymphocytes to a group of paramyxovirus antigens and to phytohemagglutinin was investigated. Comparative studies were performed in a selected group of patients before and after transfer factor therapy. There was no blastogenic response of lymphocytes to the paramyxovirus antigens tested in MS patients and normal controls, as measured by the incorporation of 14C thymidine. The stimulation index was below 2.5 even after transfer factor therapy. Lymphocyte transformation induced by PHA appeared significantly depressed in the MS patient group before transfer factor therapy when compared with the normal control group. The presence of serum factors that may depress PHA-induced lymphocyte transformation were looked for and not found. Following transfer factor therapy, an increase of the PHA response was observed in the MS group, such that a statistically significant difference in response compared with the normal control group was no longer present.
研究了多发性硬化症（MS）淋巴细胞对一组副粘病毒抗原和植物血凝素的增殖反应。在选定的一组患者中，于转移因子治疗前后进行了对比研究。通过14C胸腺嘧啶核苷掺入法测定，MS患者和正常对照中淋巴细胞对所测试的副粘病毒抗原均无增殖反应。即使在转移因子治疗后，刺激指数仍低于2.5。与正常对照组相比，在转移因子治疗前，MS患者组中由PHA诱导的淋巴细胞转化明显受到抑制。寻找但未发现可能抑制PHA诱导的淋巴细胞转化的血清因子。转移因子治疗后，MS组中观察到PHA反应增加，因此与正常对照组相比，反应上不再存在统计学上的显著差异。
