Chen David Lk, Cohen Joel L, Green Jeremy B
Department of Dermatology, University of Colorado, Aurora, USA.
AboutSkin Dermatology and DermSurgery, Englewood and Lone Tree, Colorado, USA.
Semin Cutan Med Surg. 2015 Sep;34(3):134-7. doi: 10.12788/j.sder.2015.0166.
Mesotherapy is an intradermal or subcutaneous injection of therapeutic agents to induce local effects, and was pioneered in Europe during the 1950s. For the past 2 decades, there has been significant interest in the use of mesotherapy for minimally invasive local fat contouring. Based on the theorized lipolytic effects of the agent phosphatidylcholine, initial attempts involved its injection into subcutaneous tissue. With further studies, however, it became apparent that the activity attributed to phosphatidylcholine mesotherapy was due to the adipolytic effects of deoxycholate, a detergent used to solubilize phosphatidylcholine. Since then, clinical trials have surfaced that demonstrate the efficacy of a proprietary formulation of deoxycholate for local fat contouring. Current trials on mesotherapy with salmeterol, a b-adrenergic agonist and lipolysis stimulator, are underway-with promising preliminary results as well.
中胚层疗法是将治疗药物进行皮内或皮下注射以产生局部效应，于20世纪50年代在欧洲率先开展。在过去20年里，人们对使用中胚层疗法进行微创局部脂肪塑形产生了浓厚兴趣。基于磷脂酰胆碱的理论脂解作用，最初的尝试是将其注射到皮下组织。然而，随着进一步研究，很明显，磷脂酰胆碱中胚层疗法的活性归因于脱氧胆酸盐的脂肪分解作用，脱氧胆酸盐是一种用于溶解磷脂酰胆碱的去污剂。从那时起，出现了一些临床试验，证明了一种专利配方的脱氧胆酸盐用于局部脂肪塑形的疗效。目前关于使用沙美特罗（一种β-肾上腺素能激动剂和脂解刺激剂）进行中胚层疗法的试验也正在进行，初步结果也很有前景。
