Center for Information in BioMedicine, Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
School of Political Science and Public Administration, University of Electronic Science and Technology of China, Chengdu, China.
J Neuropsychol. 2017 Sep;11(3):347-361. doi: 10.1111/jnp.12090. Epub 2015 Nov 14.
Personality dimension extraversion describes individual differences in social behaviour and socio-emotional functioning. The intrinsic functional connectivity patterns of the brain are reportedly associated with extraversion. However, whether or not extraversion is associated with functional hubs warrants clarification. Functional hubs are involved in the rapid integration of neural processing, and their dysfunction contributes to the development of neuropsychiatric disorders. In this study, we employed the functional connectivity density (FCD) method for the first time to distinguish the energy-efficient hubs associated with extraversion. The resting-state functional magnetic resonance imaging data of 71 healthy subjects were used in the analysis. Short-range FCD was positively correlated with extraversion in the left cuneus, revealing a link between the local functional activity of this region and extraversion in risk-taking. Long-range FCD was negatively correlated with extraversion in the right superior frontal gyrus and the inferior frontal gyrus. Seed-based resting-state functional connectivity (RSFC) analyses revealed that a decreased long-range FCD in individuals with high extraversion scores showed a low long-range functional connectivity pattern between the medial and dorsolateral prefrontal cortex, middle temporal gyrus, and anterior cingulate cortex. This result suggests that decreased RSFC patterns are responsible for self-esteem, self-evaluation, and inhibitory behaviour system that account for the modulation and shaping of extraversion. Overall, our results emphasize specific brain hubs, and reveal long-range functional connections in relation to extraversion, thereby providing a neurobiological basis of extraversion.
人格维度外向性描述了个体在社交行为和社会情感功能方面的差异。据报道，大脑的内在功能连接模式与外向性有关。然而，外向性是否与功能枢纽有关仍需澄清。功能枢纽参与神经处理的快速整合，其功能障碍导致神经精神障碍的发展。在这项研究中，我们首次采用功能连接密度（FCD）方法来区分与外向性相关的节能枢纽。分析使用了 71 名健康受试者的静息态功能磁共振成像数据。左楔前叶的短程 FCD 与外向性呈正相关，揭示了该区域局部功能活动与冒险行为外向性之间的联系。右额上回和额下回的长程 FCD 与外向性呈负相关。基于种子的静息态功能连接（RSFC）分析显示，高外向性评分个体的长程 FCD 降低，表现为内侧前额叶皮质、背外侧前额叶皮质、颞中回和前扣带皮质之间的长程功能连接模式降低。这一结果表明，RSFC 模式的降低负责解释外向性的调节和塑造的自尊、自我评估和抑制行为系统。总的来说，我们的研究结果强调了特定的大脑枢纽，并揭示了与外向性相关的长程功能连接，从而为外向性提供了神经生物学基础。
