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Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms.

作者信息

Stoddart Angela, Nakitandwe Joy, Chen Shann-Ching, Downing James R, Le Beau Michelle M

机构信息

Department of Medicine, University of Chicago, Chicago, IL.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.

出版信息

Blood. 2015 Dec 24;126(26):2899-901. doi: 10.1182/blood-2015-10-673228. Epub 2015 Nov 13.

DOI:10.1182/blood-2015-10-673228
PMID:26567158
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4692148/
Abstract
摘要

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Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms.多个5q基因的单倍体不足缺失可能会微调5号染色体长臂缺失（del(5q)）治疗相关髓系肿瘤中的Wnt信号通路。
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Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.逆转录病毒插入诱变确定了5号染色体长臂缺失（del(5q)）相关基因CXXC5、TIFAB和ETF1，以及Wnt信号通路，它们是del(5q)骨髓肿瘤的潜在靶点。
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Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.逆转录病毒插入诱变确定了5号染色体长臂缺失（del(5q)）相关基因CXXC5、TIFAB和ETF1，以及Wnt信号通路，它们是del(5q)骨髓肿瘤的潜在靶点。
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本文引用的文献

1
Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia.Wnt抑制剂CXXC5的下调预示急性髓系白血病预后较好。
Blood. 2015 May 7;125(19):2985-94. doi: 10.1182/blood-2014-12-613703. Epub 2015 Mar 24.
2
Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.酪蛋白激酶1A1在5号染色体长臂缺失的骨髓增生异常综合征的生物学特性及靶向治疗中的作用
Cancer Cell. 2014 Oct 13;26(4):509-20. doi: 10.1016/j.ccr.2014.08.001. Epub 2014 Sep 18.
3
Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.del(5q) 基因、Egr1 和 Apc 的单倍不足与 Tp53 缺失协同作用诱导小鼠急性髓系白血病。
Blood. 2014 Feb 13;123(7):1069-78. doi: 10.1182/blood-2013-07-517953. Epub 2013 Dec 31.
4
Downregulation but lack of promoter hypermethylation or somatic mutations of the potential tumor suppressor CXXC5 in MDS and AML with deletion 5q.5q缺失的骨髓增生异常综合征和急性髓系白血病中潜在抑癌基因CXXC5的表达下调，但缺乏启动子高甲基化或体细胞突变。
Eur J Haematol. 2013 Mar;90(3):259-60. doi: 10.1111/ejh.12045. Epub 2013 Jan 20.
5
Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.经典 Wnt 信号通路以剂量依赖的方式调控造血。
Cell Stem Cell. 2011 Oct 4;9(4):345-56. doi: 10.1016/j.stem.2011.07.017.
6
Wnt-related molecules and signaling pathway equilibrium in hematopoiesis.造血过程中的Wnt相关分子与信号通路平衡
Cell Stem Cell. 2009 Jan 9;4(1):27-36. doi: 10.1016/j.stem.2008.12.004.
7
A critical role for Apc in hematopoietic stem and progenitor cell survival.Apc在造血干细胞和祖细胞存活中起关键作用。
J Exp Med. 2008 Sep 1;205(9):2163-75. doi: 10.1084/jem.20080578. Epub 2008 Aug 25.
8
Gene expression profiling of CD34+ cells in patients with the 5q- syndrome.5q-综合征患者CD34+细胞的基因表达谱分析。
Br J Haematol. 2007 Nov;139(4):578-89. doi: 10.1111/j.1365-2141.2007.06833.x. Epub 2007 Oct 3.
9
Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis.急性髓系白血病细胞中β-连环蛋白的表达预示着克隆形成能力增强及预后不良。
Leukemia. 2006 Jul;20(7):1211-6. doi: 10.1038/sj.leu.2404239. Epub 2006 May 11.
10
Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation.糖原合酶激酶-3是造血干细胞再增殖的体内调节因子。
Nat Med. 2006 Jan;12(1):89-98. doi: 10.1038/nm1339. Epub 2005 Dec 11.