Yeo Khung Keong, Yap Jonathan, Tan Jack Wei Chieh, Lim Soo Teik, Koh Tian Hai
Department of Cardiology, National Heart Centre Singapore, Singapore.
J Invasive Cardiol. 2016 Feb;28(2):40-3. Epub 2015 Nov 15.
This study evaluates the safety and efficacy of the double-ProGlide preclose technique to secure hemostasis in patients with 24 Fr venous access.
Consecutive patients with severe mitral regurgitation undergoing the MitraClip procedure were included. All patients underwent the double-ProGlide preclose technique for closure of the femoral vein access site. Duplex ultrasound was performed at 1 month to 1 year after the procedure. The primary study outcome was a composite of major vascular complications, including: (1) the presence of >50% stenosis of the femoral vein; (2) presence of proximal deep vein thrombosis (DVT); and (3) significant venous bleeding as evidenced by >1 unit packed red blood cell transfusion within 48 hours of the procedure.
A total of 42 patients (age, 72.5 ± 9.8 years; 26 males) were included. The device was successfully deployed in all cases with successful hemostasis. No transfusions were required and no major vascular complications were noted. Thirty-five patients (83%) underwent duplex ultrasound. No femoral vein stenosis was noted on duplex ultrasound.
Off-label use of the double-ProGlide preclose technique after MitraClip therapy for closure of large-caliber femoral vein sites is both safe and efficacious.
本研究评估双ProGlide预闭合技术在24 Fr静脉通路患者中实现止血的安全性和有效性。
纳入连续接受MitraClip手术的重度二尖瓣反流患者。所有患者均采用双ProGlide预闭合技术闭合股静脉穿刺部位。术后1个月至1年进行双功超声检查。主要研究结局是主要血管并发症的综合情况，包括：（1）股静脉狭窄>50%；（2）近端深静脉血栓形成（DVT）；（3）术后48小时内输注>1单位浓缩红细胞所证实的明显静脉出血。
共纳入42例患者（年龄72.5±9.8岁；男性26例）。所有病例均成功植入该装置并成功止血。无需输血，未观察到主要血管并发症。35例患者（83%）接受了双功超声检查。双功超声检查未发现股静脉狭窄。
MitraClip治疗后将双ProGlide预闭合技术用于闭合大口径股静脉部位的非标签使用是安全有效的。
