Campese Vito M, Lakdawala Ravi
Keck School of Medicine, USC, 2020 Zonal Ave, Los Angeles, CA 90033, USA.
Recent Adv Cardiovasc Drug Discov. 2015;10(1):34-59. doi: 10.2174/1574890110666151116144725.
Hypertension is very prevalent among patients with chronic kidney disease (CKD) and end-stage kidney disease (ESRD). However, there are still several unsolved issues pertaining to the definition, variability, diagnosis and management of hypertension in these patients. This manuscript critically reviews the current challenges in clinical practice in defining, diagnosing and treating hypertension in CKD and ESRD patients. Moreover, the manuscript reviews the pharmacokinetics, pharmacodynamics and safety of most anti-hypertensive drugs used in the management of these patients.
高血压在慢性肾脏病（CKD）和终末期肾病（ESRD）患者中非常普遍。然而，在这些患者中，关于高血压的定义、变异性、诊断和管理仍有几个未解决的问题。本手稿批判性地综述了在临床实践中定义、诊断和治疗CKD和ESRD患者高血压方面的当前挑战。此外，该手稿还综述了用于管理这些患者的大多数抗高血压药物的药代动力学、药效学和安全性。
