He Zi, Liu Zhuan, Guo Kunkun, Ding Lina
College of Materials Science and Engineering, Hunan University, Changsha, 410082, China.
School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Phys Chem Chem Phys. 2015 Dec 21;17(47):31966-77. doi: 10.1039/c5cp00183h.
Cell morphodynamics during bacterial cytokinesis are theoretically explored by a combination of phase field model for rod-shaped cells and a kinetic description for FtsZ ring maintenance. The division times and cell shapes have been generally decided by the competition between the constriction forces generated by FtsZ rings and the curvature elastic energy for cells. The dependences of cell morphodynamics during bacterial cytokinesis on various kinetic rates of FtsZ filaments are focused in the present study. It is found that the obtained results with the experimental parameters are well comparable to the observed results physiologically. Likewise, the quasi-steady states for FtsZ rings are found to be well consistent with the theoretical results derived from the kinetic description of FtsZ rings. In addition, morphological phase diagram is presented as functions of the membrane associate rate for both short FtsZ filaments and free FtsZ monomers, and the depolymerization rate of GDP-bound FtsZ monomers at the tip of filaments within the ring. Our results would provide a better understanding of the details of in vivo kinetics, including the kinetic rates within FtsZ rings.
通过结合杆状细胞的相场模型和FtsZ环维持的动力学描述，从理论上探讨了细菌胞质分裂过程中的细胞形态动力学。分裂时间和细胞形状通常由FtsZ环产生的收缩力与细胞的曲率弹性能之间的竞争决定。本研究重点关注细菌胞质分裂过程中细胞形态动力学对FtsZ丝各种动力学速率的依赖性。研究发现，实验参数下获得的结果与生理上观察到的结果具有良好的可比性。同样，发现FtsZ环的准稳态与从FtsZ环的动力学描述得出的理论结果高度一致。此外，给出了形态相图，其作为短FtsZ丝和游离FtsZ单体的膜结合速率以及环内丝尖端GDP结合的FtsZ单体解聚速率的函数。我们的结果将有助于更好地理解体内动力学的细节，包括FtsZ环内的动力学速率。
