Ananthakrishna Pillai Ajith, George Geofi, Kottyen Thazhath Harichandrakumar, Yerram Sreekanth
1Department of Cardiology,Jawaharlal Institute of Postgraduate Medical Education and Research,Pondicherry,India.
2Department of Biometrics and Statistics,Jawaharlal Institute of Postgraduate Medical Education and Research,Pondicherry,India.
Cardiol Young. 2016 Oct;26(7):1266-73. doi: 10.1017/S1047951115002243. Epub 2015 Nov 16.
Different echocardiographic parameters have been studied and validated for assessing the severity of mitral stenosis; however, scant data are available for these markers in the context of balloon mitral valvuloplasty in juvenile age groups (ages ⩽20 years).
The aim of the present study was to find out the utility of echocardiographic parameters such as mitral valve separation index, left atrial volume, right ventricular systolic pressure, tricuspid annular plane systolic excursion, tricuspid annular systolic velocity, and right ventricular Tei index in predicting success of balloon mitral valvuloplasty and their relation to mitral valve area in juvenile mitral stenosis.
We carried out a prospective single-centre study involving 52 juvenile mitral stenosis patients undergoing elective valvuloplasty. Success was defined as an increase in mitral valve area ⩾50% or ⩾1.5 cm2. Echocardiographic measurements were taken before and 24 hours after the procedure and statistical analyses were carried out.
The mean age of the study population was 14.3 years (SD ±4.55), ranging from 7 to 20 years. Valvuloplasty was successful in 49 out of 52 patients. The mean valve area improved from 0.89 (SD ±0.16) to 1.73 (SD ±0.22) cm2/m2 (p<0.01), and the mean mitral valve gradient decreased from 19.87 (SD ±7.89) to 7.45 (SD ±2.07) (p=0.021). All the surrogate parameters improved favourably after valvuloplasty (p<0.01). The decrease in right ventricular systolic pressure was a better indicator of the success followed by the increase in valve separation index (area under the curve 0.81 and 0.76, respectively).
All the surrogate markers studied showed favourable improvement, and right ventricular systolic pressure reduction and improved mitral valve separation index were better indicators of successful valvuloplasty.
已经对不同的超声心动图参数进行了研究和验证,以评估二尖瓣狭窄的严重程度;然而,在青少年年龄组(年龄≤20岁)的球囊二尖瓣成形术背景下,关于这些标志物的数据很少。
本研究的目的是找出诸如二尖瓣分离指数、左心房容积、右心室收缩压、三尖瓣环平面收缩期位移、三尖瓣环收缩期速度和右心室Tei指数等超声心动图参数在预测球囊二尖瓣成形术成功方面的效用及其与青少年二尖瓣狭窄中二尖瓣面积的关系。
我们进行了一项前瞻性单中心研究,纳入了52例接受择期瓣膜成形术的青少年二尖瓣狭窄患者。成功定义为二尖瓣面积增加≥50%或≥1.5平方厘米。在手术前和手术后24小时进行超声心动图测量,并进行统计分析。
研究人群的平均年龄为14.3岁(标准差±4.55),年龄范围为7至20岁。52例患者中有49例瓣膜成形术成功。平均瓣膜面积从0.89(标准差±0.16)改善至1.73(标准差±0.22)平方厘米/平方米(p<0.01),平均二尖瓣压差从19.87(标准差±7.89)降至7.45(标准差±2.07)(p=0.021)。瓣膜成形术后所有替代参数均有良好改善(p<0.01)。右心室收缩压的降低是成功的更好指标,其次是瓣膜分离指数的增加(曲线下面积分别为0.81和0.76)。
所研究的所有替代标志物均显示出良好改善,右心室收缩压降低和二尖瓣分离指数改善是瓣膜成形术成功的更好指标。