Ushio Ryota, Yamamoto Masaki, Shibata Yuji, Ishii Hiroshi, Watanabe Keisuke, Takahashi Ryohei, Sato Takashi, Kudo Makoto, Miyake Akio, Kaneko Takeshi, Ishigatsubo Yoshiaki
Department of Respiratory Medicine, Yokohama City University Hospital, Japan.
Intern Med. 2015;54(22):2915-7. doi: 10.2169/internalmedicine.54.4940. Epub 2015 Nov 15.
Deciduoid mesothelioma is a rare variant of epithelioid mesothelioma. We experienced the case of a 73-year-old man with asbestos exposure who was diagnosed with malignant pleural mesothelioma with deciduoid features. He received chemotherapy containing six cycles of cisplatin and pemetrexed and survived for twenty-five months after the diagnosis. At autopsy, the final diagnosis was biphasic pleural mesothelioma. Cells with deciduoid features had mostly disappeared, and spindle cells markedly proliferated. To the best of our knowledge, this is the first autopsy case of malignant pleural mesothelioma with deciduoid features that exhibited a response to chemotherapy.
蜕膜样间皮瘤是上皮样间皮瘤的一种罕见变体。我们遇到了一例73岁有石棉接触史的男性患者，他被诊断为具有蜕膜样特征的恶性胸膜间皮瘤。他接受了含六个周期顺铂和培美曲塞的化疗，诊断后存活了25个月。尸检时，最终诊断为双相性胸膜间皮瘤。具有蜕膜样特征的细胞大多消失，梭形细胞明显增殖。据我们所知，这是首例对化疗有反应的具有蜕膜样特征的恶性胸膜间皮瘤尸检病例。
