Domínguez Arturo, Bayó Miquel, Muñoz-Rodríguez Jesús, Bellido Jose Antonio, Abascal-Junquera Jose María, Hannaoui Naim, Banús Josep Maria
Urology Department, Institut Català dUrologia i Nefrologia, Barcelona, Spain.
Laboratori d'anàlisis M. Bayó, Terrassa, Spain.
Korean J Urol. 2015 Nov;56(11):785-7. doi: 10.4111/kju.2015.56.11.785. Epub 2015 Nov 3.
Heterophilic antibodies are human immunoglobulins directed against various animal antigens. They can produce false-positive results in the analysis of different tumor markers, including prostate-specific antigen. This interference can lead to misdiagnosis, unnecessary tests, and overtreatment in some cases. We present herein the case of a 52-year-old man with repeated spurious elevation of prostate-specific antigen, reaching levels of 108.7 ng/mL, that were suspected to be caused by heterophilic antibodies. The interference was solved by changing the analysis technique. Real values of prostate-specific antigen were less than 1 ng/mL.
嗜异性抗体是针对各种动物抗原的人类免疫球蛋白。它们在包括前列腺特异性抗原在内的不同肿瘤标志物分析中可产生假阳性结果。这种干扰在某些情况下可能导致误诊、不必要的检查及过度治疗。我们在此报告一例52岁男性病例，其前列腺特异性抗原反复出现假性升高，达到108.7 ng/mL，怀疑是由嗜异性抗体引起的。通过改变分析技术解决了干扰问题。前列腺特异性抗原的实际值小于1 ng/mL。
