Puavilai S, Timpatanapong P
J Med Assoc Thai. 1989 Jan;72(1):33-6.
Short-course multi-drug therapy for leprosy patients was evaluated in terms of effectiveness, recurrence rate and side effects. Of the 108 patients studied, 48.1 per cent defaulted. This MDT appeared to be quite effective in controlling leprosy. The medication could be stopped at 6 months in 83 per cent of the paucibacillary patients. The medication was continued further in 17 per cent of paucibacillary patients because of persistent skin lesions clinically and histopathologically. Recurrence occurred in 2.3 per cent of the paucibacillary patients. The effect of this regimen for multibacillary patient is difficult to evaluate because of the small number of patients studied. Side effects of this regimen occurred in 5.4 per cent of the patients. Leprosy reaction occurred in two patients with borderline lepromatous leprosy.
对麻风病人采用短程多药疗法进行了有效性、复发率及副作用方面的评估。在研究的108名患者中，48.1%的患者未坚持治疗。这种多药疗法在控制麻风病方面似乎相当有效。83%的少菌型患者在6个月时即可停药。17%的少菌型患者因临床上和组织病理学上皮肤损害持续存在而继续用药。少菌型患者的复发率为2.3%。由于研究的多菌型患者数量较少，该疗法对多菌型患者的效果难以评估。该疗法的副作用发生率为5.4%。两名界线类偏瘤型麻风患者出现了麻风反应。
