孕期补充叶酸与母亲患癌风险

Supplemental folic acid in pregnancy and maternal cancer risk.

作者信息

Mortensen Jan Helge Seglem, Øyen Nina, Fomina Tatiana, Melbye Mads, Tretli Steinar, Vollset Stein Emil, Bjørge Tone

机构信息

Department of Global Public Health and Primary Care, University of Bergen, Norway; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.

Department of Global Public Health and Primary Care, University of Bergen, Norway; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.

出版信息

Cancer Epidemiol. 2015 Dec;39(6):805-11. doi: 10.1016/j.canep.2015.10.009. Epub 2015 Oct 18.

DOI:10.1016/j.canep.2015.10.009

PMID:26569032

Abstract

BACKGROUND

There is evidence that increased intake of folate protects against the development of several types of cancer. Some studies have, however, raised concern about the safety of folate in relation to cancer risk. Here we examined the risk of maternal cancer after intake of supplemental folic acid in pregnancy.

METHODS

This is a population-based cohort study comprising 429,004 women with data from the Medical Birth Registry of Norway, the Cancer Registry of Norway, and other national registries from 1999 to 2010. Altogether 3781 cancer cases were identified during follow-up (average 7 years). Cox proportional hazards regression models were used to estimate hazard ratios of maternal cancer according to folic acid use prior to and during one or two or more pregnancies as compared to no supplement use.

RESULTS

Folic acid supplementation use had no overall effect on cancer risk in women using folic acid supplementation in one (HR 1.08; 95% CI 1.00-1.18) or two or more pregnancies (HR 1.06; 95% CI 0.91-1.22) (ptrend=0.12). Analyses of 13 cancer types revealed no associations between folic acid and cancer.

CONCLUSION

Folic acid supplementation before and during pregnancy had no overall effect on maternal cancer risk.

IMPACT

Folic acid substitution before and/or during pregnancy does not increase the short-term overall maternal cancer risk.

摘要

背景

有证据表明，增加叶酸摄入量可预防多种癌症的发生。然而，一些研究对叶酸与癌症风险的安全性提出了担忧。在此，我们研究了孕期补充叶酸后母亲患癌的风险。

方法

这是一项基于人群的队列研究，纳入了429,004名女性的数据，这些数据来自挪威医疗出生登记处、挪威癌症登记处以及其他国家登记处，时间跨度为1999年至2010年。在随访期间（平均7年）共确定了3781例癌症病例。采用Cox比例风险回归模型，根据在一次或两次或更多次妊娠之前和期间使用叶酸与未使用补充剂相比，估计母亲患癌的风险比。