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印度青少年中高血压患者正常血压后代的盐味阈值及其与血压的关系

Salt taste threshold and its relation to blood pressure in normotensive offspring of hypertensive parents amongst indian adolescents.

作者信息

Nikam Lalita Harish

出版信息

Indian J Physiol Pharmacol. 2015 Jan-Mar;59(1):34-40.

Abstract

To study Salt Taste Threshold (STT) and its relation to Blood pressure (BP) in normotensive adolescents, age and BMI matched 60 subjects of 18-20 years were segregated on basis of family history of hypertension, documented risk factor for development of hypertension. Student's unpaired t-test showed that STT and BP values were significantly higher in Hypertensive offspring group than Control. Pearson Chi Square test with 60 mM Nacl as cut-off point showed highly significant association of STT in hypertensive offspring group. A significant positive correlation was found between STT and BP by Pearson correlation analysis. Family history of hypertension is strongly linked to reduced salt taste sensitivity. This reinforces rationale that both conditions may be genetically linked though causal relation cannot be established. STT can be used as significant marker to screen 'salt sensible' subjects that eventually will develop hypertension and can be advised healthy habits early or prophylactically treated.

摘要

为研究血压正常青少年的盐味阈值(STT)及其与血压(BP)的关系,选取了60名年龄和体重指数匹配的18 - 20岁受试者,根据高血压家族史(高血压发生的记录风险因素)进行分组。学生独立样本t检验显示,高血压后代组的STT和BP值显著高于对照组。以60 mM氯化钠为临界点的Pearson卡方检验显示,高血压后代组的STT存在高度显著关联。Pearson相关分析发现STT与BP之间存在显著正相关。高血压家族史与盐味敏感性降低密切相关。这强化了两种情况可能存在遗传联系的理论依据,尽管因果关系尚未确立。STT可作为一个重要指标,用于筛查最终会患高血压的“盐敏感”受试者,并可尽早建议他们养成健康习惯或进行预防性治疗。

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