Antonello Vicente Sperb, Antonello Ivan Carlos Ferreira, Santos Carlos Abaeté de Los
Departamento de Medicina Interna, Faculdade de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS.
Rev Assoc Med Bras (1992). 2007 Mar-Apr;53(2):142-6. doi: 10.1590/s0104-42302007000200019.
The study evaluates salt taste sensibility, urinary sodium excretion and blood pressure (BP) in normotensive persons. The hypothesis was that a higher salt taste threshold (STT) can be associated to a higher 24 hour natriuresis and increased BP levels.
Twenty four not hypertensive volunteers were selected. To evaluate STT, different concentrations of sodium chloride were used. Individuals were submitted to 24 hour ambulatory blood pressure monitoring (ABPM) and the 24 hour urine was collected for sodium dosage. Patients were divided in two groups related to higher or normal STT.
Both groups did not differ regarding age or body mass index (BMI). There was no difference between the groups regarding demographic variables, alcohol or tobacco use, and ABPM. Twenty-four hour natriuresis was significantly higher in the group with increased STT. Using Pearson's correlation coefficient, with the significance determined by Student-t test, there was a strong correlation between 24 hour Systolic BP and BMI, Diastolic BP and BMI, and a regular correlation between STT with 24 hour natriuresis and Systolic BP with 24 hour natriuresis.
Twenty four hour natriuresis was significantly higher in individuals with higher STT, suggesting that this avidity for salt is followed by higher ingestion of sodium. There was strong association between BP and BMI. The association between STT and BP levels was not confirmed. Increasing the number of persons, the age bracket, and of hypertensive patients may lead to a better understanding of the relations between STT, natriuresis and BP variation.
本研究评估正常血压人群的盐味敏感性、尿钠排泄及血压(BP)。假设是较高的盐味阈值(STT)可能与较高的24小时尿钠排泄及血压水平升高有关。
选取24名非高血压志愿者。为评估STT,使用了不同浓度的氯化钠。对个体进行24小时动态血压监测(ABPM),并收集24小时尿液用于钠含量测定。根据STT较高或正常将患者分为两组。
两组在年龄或体重指数(BMI)方面无差异。在人口统计学变量、饮酒或吸烟情况以及ABPM方面,两组之间也无差异。STT升高组的24小时尿钠排泄显著更高。使用Pearson相关系数,并通过Student-t检验确定显著性,24小时收缩压与BMI、舒张压与BMI之间存在强相关性,STT与24小时尿钠排泄、收缩压与24小时尿钠排泄之间存在中度相关性。
STT较高的个体24小时尿钠排泄显著更高,表明这种对盐的偏好会导致更高的钠摄入量。血压与BMI之间存在强关联。STT与血压水平之间的关联未得到证实。增加研究对象数量、年龄范围以及高血压患者数量可能有助于更好地理解STT、尿钠排泄与血压变化之间的关系。