Nakano M, Tauchi H, Katoh H, Kondoh H
Institute for Medical Science of Aging, Aichi Medical University, Japan.
Mech Ageing Dev. 1989 Jan;47(1):55-64. doi: 10.1016/0047-6374(89)90007-9.
We examined the age-related changes of renal brush border enzymes of male Donryu rats under different dietary conditions. High protein diet (51% casein) markedly decreased the activity of renal leucine aminopeptidase as compared with low protein diet (8% casein). No significant difference, however, was observed in the activity of renal maltase between high and low protein diets. Alkaline phosphatase activity from young adult (3-month-old) rats in the high protein diet group was significantly lower than that in the low protein diet groups. From these results, it is inferred that dietary conditions affect the age-related alteration of renal brush border enzymes. Together with the previous results, it is suggested that proteins of renal brush borders are altered differently during the aging process.
我们研究了不同饮食条件下雄性唐鱼大鼠肾刷状缘酶的年龄相关变化。与低蛋白饮食（8%酪蛋白）相比，高蛋白饮食（51%酪蛋白）显著降低了肾亮氨酸氨肽酶的活性。然而，高蛋白饮食和低蛋白饮食之间肾麦芽糖酶的活性没有显著差异。高蛋白饮食组中年轻成年（3个月大）大鼠的碱性磷酸酶活性显著低于低蛋白饮食组。从这些结果可以推断，饮食条件会影响肾刷状缘酶的年龄相关变化。结合之前的结果，提示肾刷状缘蛋白在衰老过程中发生了不同的变化。
