Wakabayashi Aoi, Sankaran Vijay G
Division of Hematology/Oncology, Manton Center for Orphan Disease Research, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Pediatr Res. 2016 Mar;79(3):366-70. doi: 10.1038/pr.2015.245. Epub 2015 Nov 17.
Blood cell production or hematopoiesis is one of the most well-understood paradigms of cell differentiation in the body. The majority of work on hematopoiesis comes from studies that have primarily been conducted in mice, zebrafish, or other valuable model systems. However, it is clear that such model organisms may not consistently and faithfully mimic what is observed in humans with blood disorders. Moreover, there is significant divergence between species that is increasingly being appreciated at the genomic level. As a result, there is an opportunity to use observations in humans to provide a refined view of hematopoiesis. Here, we discuss vignettes from our work that illustrate how insight from human genetics can improve our understanding of blood cell production and identify promising therapeutic approaches for blood disorders.
血细胞生成或造血作用是人体中细胞分化最被深入理解的范例之一。关于造血作用的大部分研究工作主要是在小鼠、斑马鱼或其他有价值的模型系统中进行的。然而，很明显，这些模式生物可能无法始终如一地、忠实地模拟人类血液疾病中所观察到的情况。此外，在基因组水平上，物种之间存在着越来越受到重视的显著差异。因此，有机会利用对人类的观察结果来提供对造血作用的更精确认识。在这里，我们讨论我们工作中的一些实例，这些实例说明了人类遗传学的见解如何能够增进我们对血细胞生成的理解，并为血液疾病确定有前景的治疗方法。
