Wiechert P, Marescau B, De Deyn P P, Lowenthal A
Padiatr Grenzgeb. 1989;28(2):101-6.
Patients with hyperargininemia have an arginase deficiency which leads to blockade of the urea cycle in the last step with several clinical symptoms. Owing to the arginase deficiency this patients accumulate arginine which leads to eventual alternative yet unknown pathways of arginine metabolism. These clinical and biochemical findings intensified the research on guanidino compounds. It has been shown that most of the guanidino compounds are epileptogenic. Therefore we investigated the levels of 12 guanidino compounds in serum and brain of audiogenic sensitive rats. The changes of some guanidino compounds in serum and brain will be discussed.
高精氨酸血症患者存在精氨酸酶缺乏，这会导致尿素循环在最后一步受阻，并引发多种临床症状。由于精氨酸酶缺乏，这些患者会积累精氨酸，进而导致精氨酸代谢出现未知的替代途径。这些临床和生化发现加强了对胍基化合物的研究。已表明大多数胍基化合物具有致癫痫性。因此，我们研究了听源性敏感大鼠血清和脑中12种胍基化合物的水平。将讨论血清和脑中一些胍基化合物的变化。
