Luo Qiyi, Huang Chubo, Wang Shuai, Meng Juan, Li Zhonghua, Chang Zhaohua, Zhu Yufang, Hua Zezhao
College of Medical and Food Engineering, University of Shanghai Science and Technology, Shanghai, China.
Shanghai MicroPort Medical (Group) Co., Ltd., Shanghai, China.
Cardiovasc Eng Technol. 2015 Mar;6(1):71-9. doi: 10.1007/s13239-014-0199-1. Epub 2014 Nov 11.
This comparative study investigated the biodegradation behavior and mechanism of bioresorbable cardiovascular scaffolds using bench testing under physiological conditions and in vivo experiment. The results show that the molecular weight of the scaffold decreased with respect to time after implantation in both in vivo and in vitro tests. It was found that the molecular weights of the implanted scaffolds in the in vivo and in vitro models decreased to 61.8 and 68.5% respectively 6 months after implantation, but the thermodynamic properties of the scaffold material were not significantly affected by the 6-month degradation. Moreover, the study indicated that in spite of the 6-month degradation, the scaffold maintained sufficient radial strength and mechanical integrity. Furthermore, it was noted that the changes in the trends of the mechanical properties and degradation behavior of the scaffolds in the in vitro model were coherent with the results of the in vivo study, which means the in vitro study of the degradation behavior of polylactic acid (PLA) scaffold could offer clinical relevant data and physical insights to predict the in vivo performance.
这项比较研究在生理条件下通过台架试验和体内实验，研究了生物可吸收心血管支架的生物降解行为及机制。结果表明，在体内和体外试验中，植入后支架的分子量均随时间降低。研究发现，体内和体外模型中植入支架的分子量在植入6个月后分别降至61.8%和68.5%，但6个月的降解对支架材料的热力学性质没有显著影响。此外，该研究表明，尽管经过6个月的降解，支架仍保持足够的径向强度和机械完整性。此外，还注意到体外模型中支架的力学性能和降解行为趋势变化与体内研究结果一致，这意味着聚乳酸（PLA）支架降解行为的体外研究可为预测体内性能提供临床相关数据和物理见解。
