Morrell Kathleen M, Cremers Serge, Westhoff Carolyn L, Davis Anne R
Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W 168th Street, PH 16-69, New York, NY, 10032, USA.
Biomarkers Core Laboratory, Irving Institute for Clinical and Translational Research, Columbia University Medical Center, 630 W 168th Street, PH 10-105b, New York, NY, 10027, USA.
Contraception. 2016 Mar;93(3):263-5. doi: 10.1016/j.contraception.2015.11.005. Epub 2015 Nov 11.
Progestin-only contraceptive methods, including the 3-year, single-rod etonogestrel (ENG) implant, may be preferred for obese women to avoid additional estrogen-related thrombosis risk; however, whether obese women receive an ENG sufficient dose to suppress ovulation is understudied. Our analysis expands on the limited information currently available by studying ENG levels related to body mass index (BMI) in a community sample of primarily Hispanic women. This cross-sectional, descriptive study of 52 long-term implant users found comparable ENG levels across a wide BMI range (p=.1). These results further support that ENG levels are independent of BMI through 3 years of implant use and are thus reassuring that ENG implants will be effective for women of all BMIs.
仅含孕激素的避孕方法，包括3年期单棒式依托孕烯（ENG）植入剂，对于肥胖女性可能是更好的选择，以避免额外的雌激素相关血栓形成风险；然而，肥胖女性是否能获得足以抑制排卵的ENG剂量尚未得到充分研究。我们的分析通过在主要为西班牙裔女性的社区样本中研究与体重指数（BMI）相关的ENG水平，扩展了目前有限的可用信息。这项对52名长期植入剂使用者的横断面描述性研究发现，在广泛的BMI范围内，ENG水平相当（p = 0.1）。这些结果进一步支持，在植入使用的3年中，ENG水平与BMI无关，因此可以放心，ENG植入剂对所有BMI的女性都将有效。
