Schofer O, Buettner H J, Kraemer M, Zepp F, Mannhardt W
Department of Paediatrics, University Hospital Mainz, FRG.
Scand J Immunol. 1989 May;29(5):627-9. doi: 10.1111/j.1365-3083.1989.tb01166.x.
When bone marrow transplantation recipients undergo standard pre-transplant immunosuppressive therapy, engraftment failures are significantly more frequent with the use of T-depleted allogeneic donor bone marrow cells than with T cell-containing allogeneic donor bone marrow cells. The relative importance of T versus natural killer (NK) cells in the rejection process of T-depleted donor bone marrow cells remains debatable. Here, NK- and T-deficient mouse mutants were transplanted across the same major histocompatibility complex (MHC) differences with homozygous or heterozygous T-depleted bone marrow cells. Results show that under the experimental conditions described, residual host NK cells are almost exclusively responsible for the increased rejection rate.
当骨髓移植受者接受标准的移植前免疫抑制治疗时，使用去除T细胞的同种异体供体骨髓细胞比使用含T细胞的同种异体供体骨髓细胞，植入失败的情况明显更频繁。在去除T细胞的供体骨髓细胞的排斥过程中，T细胞与自然杀伤（NK）细胞的相对重要性仍存在争议。在此，将NK和T细胞缺陷的小鼠突变体与纯合或杂合的去除T细胞的骨髓细胞进行相同主要组织相容性复合体（MHC）差异的移植。结果表明，在所描述的实验条件下，残留的宿主NK细胞几乎完全导致了排斥率的增加。
