沙特人类基因组计划：阿拉伯医学荒漠中的一片绿洲，正在为遗传疾病提供线索。

The Saudi Human Genome Program: An oasis in the desert of Arab medicine is providing clues to genetic disease.

作者信息

Project Team Saudi Genome

出版信息

IEEE Pulse. 2015 Nov-Dec;6(6):22-6. doi: 10.1109/MPUL.2015.2476541.

DOI:10.1109/MPUL.2015.2476541

Abstract

Oil wells, endless deserts, stifling heat, masses of pilgrims, and wealthy-looking urban areas still dominate the widespread mental image of Saudi Arabia. Currently, this image is being extended to include a recent endeavor that is reserving a global share in the limelight as one of the top ten genomics projects currently underway: the Saudi Human Genome Program (SHGP). With sound funding, dedicated resources, and national determination, the SHGP targets the sequencing of 100,000 human genomes over the next five years to conduct world-class genomics-based biomedical research in the Saudi population. Why this project was conceived and thought to be feasible, what is the ultimate target, and how it operates are the questions we answer in this article.

摘要

油井、无垠的沙漠、令人窒息的酷热、大批朝圣者以及看似繁华的城市地区，依旧主导着人们对沙特阿拉伯的普遍印象。目前，这一印象正进一步扩展，将一项近期的努力涵盖其中，该努力作为当前正在进行的十大基因组计划之一，在全球备受瞩目：沙特人类基因组计划（SHGP）。凭借充足的资金、专用资源以及国家决心，沙特人类基因组计划的目标是在未来五年内对10万个人类基因组进行测序，以便在沙特人群中开展世界级的基于基因组学的生物医学研究。本文将回答该项目为何构思并被认为可行、最终目标是什么以及如何运作等问题。