• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

熵分析揭示了癌症复发与化疗之间的联系。

Entropic analysis reveals a connection between the recurrence of cancer and chemotherapy.

作者信息

Tseng Chih-Yuan, Tuszynski Jack

机构信息

MDT Canada Inc., Edmonton, AB, Canada.

Department of Oncology, University of Alberta, Edmonton, AB T6G 1Z2, Canada ; Department of Physics, University of Alberta, Edmonton, AB, Canada.

出版信息

Saudi J Biol Sci. 2015 Nov;22(6):674-8. doi: 10.1016/j.sjbs.2015.05.005. Epub 2015 May 13.

DOI:10.1016/j.sjbs.2015.05.005
PMID:26586992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4625121/
Abstract

In this study, we proposed an entropic analysis to overcome limitations of conventional statistical methods to analyze clinical data for cancer patients who experienced relapse of tumors following chemotherapy. We have applied this entropic method to reveal potential mechanisms that lead to a relapse of Wilms' tumor in pediatric patients. Results indicate β-tubulin isotype III up-regulation is likely the primary cause of the relapse.

摘要

在本研究中，我们提出了一种熵分析方法，以克服传统统计方法在分析化疗后肿瘤复发的癌症患者临床数据方面的局限性。我们已应用这种熵方法来揭示导致小儿患者肾母细胞瘤复发的潜在机制。结果表明，β-微管蛋白同种型III的上调可能是复发的主要原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7999/4625121/67e0c2e0f037/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7999/4625121/60de4fcc2445/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7999/4625121/67e0c2e0f037/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7999/4625121/60de4fcc2445/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7999/4625121/67e0c2e0f037/gr2.jpg

相似文献

1
Entropic analysis reveals a connection between the recurrence of cancer and chemotherapy.熵分析揭示了癌症复发与化疗之间的联系。
Saudi J Biol Sci. 2015 Nov;22(6):674-8. doi: 10.1016/j.sjbs.2015.05.005. Epub 2015 May 13.
2
Localization of the neuronal class III beta-tubulin isotype in foci of early neuritogenesis supports divergent neuroblastic differentiation potential in Wilms' tumors.神经元III类β-微管蛋白亚型在早期神经突发生灶中的定位支持肾母细胞瘤中不同的成神经细胞分化潜能。
Arch Pathol Lab Med. 1994 Oct;118(10):1002-6.
3
Incidence and outcomes of patients with late recurrence of Wilms' tumor.Wilms 瘤患者迟发复发的发生率和结局。
Pediatr Blood Cancer. 2013 Oct;60(10):1612-5. doi: 10.1002/pbc.24604. Epub 2013 Jun 4.
4
Role of chest computed tomography at diagnosis in the management of Wilms' tumor: a study by the United Kingdom Children's Cancer Study Group.胸部计算机断层扫描在肾母细胞瘤诊断及管理中的作用：英国儿童癌症研究小组的一项研究
J Clin Oncol. 2002 Jun 15;20(12):2768-73. doi: 10.1200/JCO.2002.02.147.
5
Wilms' tumor: past, present and (possibly) future.肾母细胞瘤：过去、现在及（可能的）未来
Expert Rev Anticancer Ther. 2006 Feb;6(2):249-58. doi: 10.1586/14737140.6.2.249.
6
Clinical factors in relapses of Wilms' tumor--results for the Polish Pediatric Solid Tumors Study Group.肾母细胞瘤复发的临床因素——波兰儿童实体瘤研究组的结果
Adv Clin Exp Med. 2014 Nov-Dec;23(6):925-31. doi: 10.17219/acem/37340.
7
P-glycoprotein status of favorable-histology Wilms' tumor predicts treatment outcome.组织学类型良好的肾母细胞瘤的P-糖蛋白状态可预测治疗结果。
J Pediatr Surg. 1994 Aug;29(8):1080-3; discussion 1084. doi: 10.1016/0022-3468(94)90283-6.
8
Etoposide in relapsed or refractory Wilms' tumor: a phase II study by the French Society of Pediatric Oncology and the United Kingdom Children's Cancer Study Group.依托泊苷用于复发或难治性肾母细胞瘤：法国儿科肿瘤学会和英国儿童癌症研究组的一项II期研究
J Clin Oncol. 1993 Aug;11(8):1478-81. doi: 10.1200/JCO.1993.11.8.1478.
9
Treatment outcomes in patients less than 2 years of age with small, stage I, favorable-histology Wilms' tumors: a report from the National Wilms' Tumor Study.小于2岁的小的、I期、组织学良好的威尔姆斯瘤患者的治疗结果：来自国家威尔姆斯瘤研究的报告
J Clin Oncol. 1993 Jan;11(1):91-5. doi: 10.1200/JCO.1993.11.1.91.
10
The role of surgical excision in the management of relapsed Wilms' tumor patients with pulmonary metastases: a report from the National Wilms' Tumor Study.手术切除在复发性伴有肺转移的肾母细胞瘤患者治疗中的作用：来自国家肾母细胞瘤研究的报告
J Pediatr Surg. 1991 Jun;26(6):728-33. doi: 10.1016/0022-3468(91)90021-k.

本文引用的文献

1
Functional cloning of recurrence-specific antigens identifies molecular targets to treat tumor relapse.功能克隆复发特异性抗原鉴定分子靶标治疗肿瘤复发。
Mol Ther. 2013 Aug;21(8):1507-16. doi: 10.1038/mt.2013.116. Epub 2013 Jun 11.
2
Determination of the optimal tubulin isotype target as a method for the development of individualized cancer chemotherapy.确定最佳微管蛋白亚型靶点作为个体化癌症化疗发展的一种方法。
Theor Biol Med Model. 2013 May 1;10:29. doi: 10.1186/1742-4682-10-29.
3
Stressors, stress response, and cancer recurrence: a systematic review.
Cancer Nurs. 2014 Mar-Apr;37(2):114-25. doi: 10.1097/NCC.0b013e318289a6e2.
4
Comparative modelling of human β tubulin isotypes and implications for drug binding.人β微管蛋白亚型的比较建模及其对药物结合的影响。
Nanotechnology. 2006 Feb 28;17(4):S90-S100. doi: 10.1088/0957-4484/17/4/014. Epub 2006 Feb 2.
5
Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives.定量分析微管蛋白同工型表达对一组新型秋水仙碱衍生物敏感的癌细胞系的影响。
Mol Cancer. 2010 May 30;9:131. doi: 10.1186/1476-4598-9-131.
6
Tumoral and tissue-specific expression of the major human beta-tubulin isotypes.主要人β微管蛋白同工型的肿瘤和组织特异性表达。
Cytoskeleton (Hoboken). 2010 Apr;67(4):214-23. doi: 10.1002/cm.20436.
7
The roles of beta-tubulin mutations and isotype expression in acquired drug resistance.β-微管蛋白突变和亚型表达在获得性耐药中的作用。
Cancer Inform. 2007 Apr 27;3:159-81.
8
An integrative model for recurrence in ovarian cancer.卵巢癌复发的综合模型。
Mol Cancer. 2008 Jan 22;7:8. doi: 10.1186/1476-4598-7-8.
9
Role of HER2 in wound-induced breast carcinoma proliferation.HER2在创伤诱导的乳腺癌增殖中的作用。
Lancet. 2003 Aug 16;362(9383):527-33. doi: 10.1016/S0140-6736(03)14112-8.