Desai Shyamal D
Department of Biochemistry & Molecular Biology; LSU Health Sciences Center-School of Medicine ; New Orleans, LA USA.
Oncoimmunology. 2015 Jun 1;4(12):e1052935. doi: 10.1080/2162402X.2015.1052935. eCollection 2015 Dec.
() transcript is aberrantly expressed in most human malignancies, suggesting that it has a protumor function. However, at the protein level ISG15 has both protumor and immunomodulatory antitumor functions. Therapeutic strategies to maximize the latter may benefit cancer patients overexpressing the ISG15 pathway.
()转录本在大多数人类恶性肿瘤中异常表达,表明它具有促肿瘤功能。然而,在蛋白质水平上,ISG15具有促肿瘤和免疫调节抗肿瘤功能。最大化后者的治疗策略可能会使过表达ISG15途径的癌症患者受益。