SUMO-mediated global and local control of recombination.
作者信息
Urulangodi Madhusoodanan, Szakal Barnabas, Branzei Dana
机构信息
a IFOM, the FIRC Institute of Molecular Oncology , Milan , Italy.
出版信息
Cell Cycle. 2016;15(2):160-1. doi: 10.1080/15384101.2015.1118918. Epub 2015 Nov 20.
Abstract
摘要
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Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication.
Genes Dev. 2015 Oct 1;29(19):2067-80. doi: 10.1101/gad.265629.115.
2
DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity.
EMBO J. 2014 Feb 18;33(4):327-40. doi: 10.1002/embj.201387425. Epub 2014 Jan 28.
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Human mutation rate associated with DNA replication timing.
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SUMOylation regulates Rad18-mediated template switch.
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Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p.
Mol Cell. 2005 Jul 1;19(1):123-33. doi: 10.1016/j.molcel.2005.06.001.
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SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase.
Nature. 2005 Jul 21;436(7049):428-33. doi: 10.1038/nature03665. Epub 2005 Jun 1.
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RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.
Nature. 2002 Sep 12;419(6903):135-41. doi: 10.1038/nature00991.
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