Treanor John Jay
Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 689, 601 Elmwood Avenue, Rochester, NY 14642, United States.
Am J Prev Med. 2015 Dec;49(6 Suppl 4):S355-63. doi: 10.1016/j.amepre.2015.09.012.
The development of vaccines that could provide broad protection against antigenically variant influenza viruses has long been the ultimate prize in influenza research. Recent developments have pushed us closer to this goal, and such vaccines may now be within reach. This brief review outlines the current approaches to broadly protective vaccines, and the probable hurdles and roadblocks to achieving this goal.
开发能够对抗原性变异的流感病毒提供广泛保护的疫苗,长期以来一直是流感研究的终极目标。最近的进展使我们离这个目标更近了,此类疫苗现在或许已触手可及。本简要综述概述了目前研发广泛保护性疫苗的方法,以及实现这一目标可能遇到的障碍。