广谱保护性流感疫苗的前景。

Prospects for broadly protective influenza vaccines.

作者信息

Treanor John Jay

机构信息

Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 689, 601 Elmwood Avenue, Rochester, NY 14642, United States.

出版信息

Vaccine. 2015 Nov 27;33 Suppl 4:D39-45. doi: 10.1016/j.vaccine.2015.08.053. Epub 2015 Sep 1.

DOI:10.1016/j.vaccine.2015.08.053

PMID:26338145

Abstract

The development of vaccines that could provide broad protection against antigenically variant influenza viruses has long been the ultimate prize in influenza research. Recent developments have pushed us closer to this goal, and such vaccines may now be within reach. This brief review outlines the current approaches to broadly protective vaccines, and the probable hurdles and roadblocks to achieving this goal.

摘要

研发能够对抗原性变异流感病毒提供广泛保护的疫苗，长期以来一直是流感研究的终极目标。近期的进展使我们离这一目标更近了，此类疫苗或许即将问世。本简要综述概述了目前研发广泛保护性疫苗的方法，以及实现这一目标可能面临的障碍。