足底电击和心理应激诱导创伤后“噩梦”突然觉醒的潜在机制
Mechanisms Underlying Footshock and Psychological Stress-Induced Abrupt Awakening From Posttraumatic "Nightmares".
作者信息
Yu Bin, Cui Su-Ying, Zhang Xue-Qiong, Cui Xiang-Yu, Li Sheng-Jie, Sheng Zhao-Fu, Cao Qing, Huang Yuan-Li, Xu Ya-Ping, Lin Zhi-Ge, Yang Guang, Song Jin-Zhi, Ding Hui, Zhang Yong-He
机构信息
Department of Pharmacology, Peking University, School of Basic Medical Science, 38 Xueyuan Road, Beijing, 100191, China (Ms Yu, Zhang, Li, Cao, Song, and Ding, Drs S-Y Cui, X-Y Cui, and Y-H Zhang, and Mr Sheng, Huang, Xu, Lin and Yang).
出版信息
Int J Neuropsychopharmacol. 2016 Apr 20;19(4). doi: 10.1093/ijnp/pyv113. Print 2016 Apr.
BACKGROUND
Posttraumatic nightmares are a highly prevalent and distressing symptom of posttraumatic stress disorder (PTSD), but have been the subject of limited phenomenological investigations.
METHODS
We utilized a communication box to establish PTSD symptoms in rats through exposure to footshock stress (FS) and psychological stress (PS). The immunohistochemical test and high-performance liquid chromatography with electrochemical detection were used to detect the activity and monoamine levels in the rats' arousal systems.
RESULTS
Twenty-one days after traumatic stress, 14.17% of FS and 12.5% of PS rats exhibited startled awakening, and the same rats showed hyperfunction of the locus coeruleus/noradrenergic system and hypofunction of the perifornical nucleus/orexinergic system. Changes in serotonin levels in the dorsal raphe nucleus showed opposite trends in the FS and PS rats that were startled awake. No differences were found in other sleep/arousal systems.
CONCLUSION
These results suggest that different clinically therapeutic strategies should be considered to treat different trauma-induced posttraumatic nightmares.
背景
创伤后噩梦是创伤后应激障碍（PTSD）中一种非常普遍且令人痛苦的症状，但一直是现象学研究有限的主题。
方法
我们利用一个通讯箱，通过暴露于足部电击应激（FS）和心理应激（PS）在大鼠中建立PTSD症状。采用免疫组织化学试验和高效液相色谱电化学检测法检测大鼠觉醒系统中的活性和单胺水平。
结果
创伤应激21天后，14.17%的FS组大鼠和12.5%的PS组大鼠出现惊跳觉醒，且相同大鼠表现出蓝斑/去甲肾上腺素能系统功能亢进和穹窿周核/食欲素能系统功能减退。在惊跳觉醒的FS组和PS组大鼠中，中缝背核中5-羟色胺水平的变化呈现相反趋势。在其他睡眠/觉醒系统中未发现差异。
结论
这些结果表明，应考虑采用不同的临床治疗策略来治疗不同创伤所致的创伤后噩梦。
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