Snikhovskaya K V, Shabalova I P
Klin Lab Diagn. 2015 Aug;60(8):32-6.
The cytological technique takes a leading position in diagnostic of tumor processes according exudative fluids. However, its results depend on large number of subjective factors. The morphometry is one of techniques by virtue of which objectification of data of cytological analysis is possible. The study was carried out to establish differences of morphometric parameters of benign and malignant cells of pleural effusion. The morphometric analysis of cells of mesothelium, breast cancer, adenocarcinoma of lung and adenocarcinoma of stomach was implemented. The parameters characterizing size (area, perimeter) and form (form factor) of nucleus and cell, nucleus-cytoplasm ratio. The results demonstrated that in pleural effusion between cells of proliferating mesothelium and malignant neoplasms exist significant differences in morphometric parameters (p<0.001). The differences between area of nuclei and cells are especially significant. The comparison of data of morphometry of cells of breast cancer; adenocarcinoma of lung and adenocarcinoma of stomach demonstrated that despite of some morphological similarities, analysis of morphometric parameters can provide important data for proper establishment of cytological diagnosis.
根据渗出液，细胞学技术在肿瘤病变诊断中占据主导地位。然而，其结果取决于大量主观因素。形态计量学是实现细胞学分析数据客观化的技术之一。开展该研究以确定胸腔积液中良性和恶性细胞形态计量参数的差异。对间皮细胞、乳腺癌、肺腺癌和胃腺癌的细胞进行了形态计量分析。表征细胞核和细胞大小（面积、周长）和形态（形态因子）、核质比的参数。结果表明，在胸腔积液中，增殖间皮细胞与恶性肿瘤细胞之间的形态计量参数存在显著差异（p<0.001）。细胞核和细胞面积之间的差异尤为显著。乳腺癌、肺腺癌和胃腺癌细胞形态计量数据的比较表明，尽管存在一些形态学相似性，但形态计量参数分析可为正确建立细胞学诊断提供重要数据。
