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AB - BA交叉试验下计数数据的影响诊断

Influence diagnostics for count data under AB-BA crossover trials.

作者信息

Hao Chengcheng, von Rosen Dietrich, von Rosen Tatjana

机构信息

1 Department of Statistics, Stockholm University, Stockholm, Sweden.

2 Department of Energy and Technology, Swedish University of Agricultural Sciences, Uppsala, Sweden.

出版信息

Stat Methods Med Res. 2017 Dec;26(6):2938-2950. doi: 10.1177/0962280215615597. Epub 2015 Nov 23.

Abstract

This paper aims to develop diagnostic measures to assess the influence of data perturbations on estimates in AB-BA crossover studies with a Poisson distributed response. Generalised mixed linear models with normally distributed random effects are utilised. We show that in this special case, the model can be decomposed into two independent sub-models which allow to derive closed-form expressions to evaluate the changes in the maximum likelihood estimates under several perturbation schemes. The performance of the new influence measures is illustrated by simulation studies and the analysis of a real dataset.

摘要

本文旨在开发诊断方法,以评估数据扰动对具有泊松分布响应的AB - BA交叉研究中估计值的影响。使用了具有正态分布随机效应的广义混合线性模型。我们表明,在这种特殊情况下,该模型可以分解为两个独立的子模型,这使得我们能够推导出封闭形式的表达式,以评估在几种扰动方案下最大似然估计值的变化。通过模拟研究和对一个真实数据集的分析,展示了新影响度量的性能。

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